RT1-Bα Antibody (6A603): sc-71979

RT1-Bα Antibody (6A603) is a mouse monoclonal IgG1 antibody that detects RT1-B alpha protein of mouse and rat origin by immunofluorescence (IF). Anti-RT1-B alpha antibody (6A603) is available as non-conjugated format, providing researchers with a reliable tool for studying the major histocompatibility complex (MHC) in rats, which plays a crucial role in immune response. RT1-B alpha (6A603) monoclonal antibody recognizes a dimer composed of an alpha and beta glycoprotein chain, homologous to the I-A and I-E genes found in the H-2 complex of mice. Understanding RT1-B structure is vital, as this directly influences antigen presentation to T helper cells, thereby facilitating immune recognition and response. MHC Class II antigens, such as RT1-B, are essential for studying interactions between T helper cells and class II positive antigen-presenting cells, including dendritic cells, B cells, and macrophages. RT1-B alpha (6A603) antibody can also stain stromal cells in the thymus, offering new insights into T helper cell development and overall dynamics of the immune system.

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RT1-Bα Antibody (6A603) References:

1. Complementary DNA sequences encoding the rat MHC class II RT1-Bu and RT1-Du alpha and beta chains.  |  Easterfield, AJ., et al. 2003. Immunogenetics. 55: 344-50. PMID: 12879310
2. Open reading frame sequencing and structure-based alignment of polypeptides encoded by RT1-Bb, RT1-Ba, RT1-Db, and RT1-Da alleles.  |  Ettinger, RA., et al. 2004. Immunogenetics. 56: 585-96. PMID: 15517241
3. Considerable haplotypic diversity in the RT1-CE class I gene region of the rat major histocompatibility complex.  |  Roos, C. and Walter, L. 2005. Immunogenetics. 56: 773-7. PMID: 15578174
4. Novel antibody tags from the rat lysosomal protein RT1.DM for immunodetection of recombinant proteins.  |  Neumann, J. 2005. J Immunol Methods. 301: 66-76. PMID: 15896798
5. Complete coding nucleotide sequence of cDNA for the class II RT1.B beta I chain of the Lewis rat.  |  Syha-Jedelhauser, J., et al. 1991. Biochim Biophys Acta. 1089: 414-6. PMID: 1859846
6. Polymorphism of the class II gene of rat major histocompatibility complex, RT1: partial sequence comparison of the first domain of the RT1.B beta 1 alleles.  |  Fujii, H., et al. 1991. Immunogenetics. 33: 399-403. PMID: 1904838
7. Elevated mRNA levels of major histocompatibility complex class II genes in lymphocytes of autoimmune BB rats.  |  Holowachuk, EW., et al. 1988. Diabetes. 37: 1637-40. PMID: 3142800
8. Ir gene for bovine insulin in the rat maps to RT1.B beta.  |  Mizuno, K., et al. 1987. J Immunogenet. 14: 159-62. PMID: 3121753