Molecular structure of (RS)-MCPG, CAS Number: 146669-29-6
(RS)-MCPG (CAS 146669-29-6)
Alternate Names:
(±)-α-Methyl-(4-carboxyphenyl)glycine
Application:
(RS)-MCPG is a non-selective group I/group II metabotropic glutamate receptor antagonist
CAS Number:
146669-29-6
Purity:
≥97%
Molecular Weight:
209.2
Molecular Formula:
C10H11NO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
(RS)-MCPG, or (RS)-alpha-methyl-4-carboxyphenylglycine, is a non-selective antagonist of group I/II metabotropic glutamate receptors (mGluR). (RS)-MCPG is employed as a tool for probing the mGluR system and elucidating the role of mGluRs in biological processes. (RS)-MCPG is described to block spatial learning in rats through interaction at the group I mGluR. (RS)-MCPG was also used as a tool to demonstrate that synaptic activation of mGluR is necessary for the induction of long-term potentiation in the hippocampus. The isomer (S)-MCPG (sc-202329) is described to be the active isomer of the (RS)-MCPG preparation. (RS)-MCPG is an inhibitor of mGluR-1a, mGluR-1b, mGluR-2, mGluR-3 and mGluR-5.
(RS)-MCPG (CAS 146669-29-6) References
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- Competitive antagonism at metabotropic glutamate receptors by (S)-4-carboxyphenylglycine and (RS)-alpha-methyl-4-carboxyphenylglycine. | Eaton, SA., et al. 1993. Eur J Pharmacol. 244: 195-7. PMID: 8381746
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- Molecular cloning, functional expression, pharmacological characterization and chromosomal localization of the human metabotropic glutamate receptor type 3. | Emile, L., et al. 1996. Neuropharmacology. 35: 523-30. PMID: 8887960
- Absolute configuration of (+)-alpha-methyl-4-carboxyphenylglycine (MCPG), a metabotropic glutamate receptor antagonist. | Wilson, C., et al. 1997. Acta Crystallogr C. 53 (Pt 7): 909-11. PMID: 9241811
- Modulation of excitatory synaptic transmission in locus coeruleus by multiple presynaptic metabotropic glutamate receptors. | Dubé, GR. and Marshall, KC. 1997. Neuroscience. 80: 511-21. PMID: 9284353
- Intracellular Ca2+ release mediated by metabotropic glutamate receptor activation in the leech giant glial cell. | Lohr, C. and Deitmer, JW. 1997. J Exp Biol. 200: 2565-73. PMID: 9366087
- (R,S)-alpha-methyl-4-carboxyphenylglycine (MCPG) fails to block long-term potentiation under urethane anaesthesia in vivo. | Martin, SJ. and Morris, RG. 1997. Neuropharmacology. 36: 1339-54. PMID: 9423922
- (+)-MCPG blocks induction of LTP in CA1 of rat hippocampus via agonist action at an mGluR group II receptor. | Breakwell, NA., et al. 1998. J Neurophysiol. 79: 1270-6. PMID: 9497408
- Inhibition of group I metabotropic glutamate receptors blocks spatial learning in rats. | Balschun, D. and Wetzel, W. 1998. Neurosci Lett. 249: 41-4. PMID: 9672384
- The metabotropic glutamate receptor antagonist (RS)-MCPG produces hyperlocomotion in amphetamine pre-exposed rats. | Kim, JH. and Vezina, P. 1998. Neuropharmacology. 37: 189-97. PMID: 9680243
Inhibitor of:
mGluR-1a, mGluR-1b, mGluR-2, mGluR-3, mGluR-5, and mGLuR-8.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(RS)-MCPG, 5 mg | sc-202325 | 5 mg | $137.00 |