(RS)-CPPG is the most potent group II/III mGluR antagonist, with approx. 20-fold selectivity for group III over group II. (RS)-CPPG is an inhibitor of mGluR-2, mGluR-3, mGluR-4, mGluR-6, mGluR-7 and mGLuR-8.
1. Toms, N.J., et al. 1996. Br. J. Pharmacol. 119: 851-854. PMID: 8922731 2. Jane, D.E., et al. 1996. Neuropharmacology 35: 1029-1035. PMID: 9121605 3. Schoepp, D.D., et al. 1999. Neuropharmacology. 38: 1431-1476. PMID: 10530808
Soluble in water (>5 mg/ml), dilute aqueous base, and NaOH (100 mM, 27mg/100mM NaOH = 100mM stock at pH7).
Store at 4° C
304.03° C (Predicted)
541.54° C at 760 mmHg (Predicted)
1.57 g/cm3 (Predicted)
n20D 1.65 (Predicted)
mGlu group III : IC50 = 2.2 nM; mGlu group II: IC50 = 46.2 nM
pKa: 1.55 (Predicted), pKb: 10.39 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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(RS)-CPPG (CAS 183364-82-1)
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