Molecular structure of RS 504393, CAS Number: 300816-15-3
RS 504393 (CAS 300816-15-3)
See product citations (4)
Application:
RS 504393 is an extremely selective CCR2 chemokine receptor antagonist and inhibitor of MCP-1 chemotaxis
CAS Number:
300816-15-3
Purity:
≥97%
Molecular Weight:
417.5
Molecular Formula:
C25H27N3O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
RS 504393 is a potent and selective inhibitor of the p38 mitogen-activated protein (MAP) kinase. It is used to study the role of p38 MAP kinase in various cellular processes. RS 504393 inhibits the activity of p38 MAP kinase, which is involved in the regulation of cell proliferation, differentiation, and apoptosis. RS 504393 is for investigating the signaling pathways that are mediated by p38 MAP kinase.
RS 504393 (CAS 300816-15-3) References
- Identification of the binding site for a novel class of CCR2b chemokine receptor antagonists: binding to a common chemokine receptor motif within the helical bundle. | Mirzadegan, T., et al. 2000. J Biol Chem. 275: 25562-71. PMID: 10770925
- CCR2 signaling contributes to ischemia-reperfusion injury in kidney. | Furuichi, K., et al. 2003. J Am Soc Nephrol. 14: 2503-15. PMID: 14514728
- Blockade of CCR2 ameliorates progressive fibrosis in kidney. | Kitagawa, K., et al. 2004. Am J Pathol. 165: 237-46. PMID: 15215179
- Blocking mast cell-mediated type I hypersensitivity in experimental allergic conjunctivitis by monocyte chemoattractant protein-1/CCR2. | Tominaga, T., et al. 2009. Invest Ophthalmol Vis Sci. 50: 5181-8. PMID: 19553621
- Thrombin stimulates RPE cell motility by PKC-zeta- and NF-kappaB-dependent gene expression of MCP-1 and CINC-1/GRO chemokines. | Palma-Nicolás, JP., et al. 2010. J Cell Biochem. 110: 948-67. PMID: 20564194
- CCL2 released at tumoral level contributes to the hyperalgesia evoked by intratibial inoculation of NCTC 2472 but not B16-F10 cells in mice. | Pevida, M., et al. 2012. Naunyn Schmiedebergs Arch Pharmacol. 385: 1053-61. PMID: 22976830
- Spinal CCL2 and microglial activation are involved in paclitaxel-evoked cold hyperalgesia. | Pevida, M., et al. 2013. Brain Res Bull. 95: 21-7. PMID: 23562605
- Involvement of spinal chemokine CCL2 in the hyperalgesia evoked by bone cancer in mice: a role for astroglia and microglia. | Pevida, M., et al. 2014. Cell Mol Neurobiol. 34: 143-56. PMID: 24122510
- Inhibiting the mobilization of Ly6C(high) monocytes after acute myocardial infarction enhances the efficiency of mesenchymal stromal cell transplantation and curbs myocardial remodeling. | Lu, W., et al. 2015. Am J Transl Res. 7: 587-97. PMID: 26045897
- Analgesic effects evoked by a CCR2 antagonist or an anti-CCL2 antibody in inflamed mice. | Llorián-Salvador, M., et al. 2016. Fundam Clin Pharmacol. 30: 235-47. PMID: 26820818
- CCL2/CCR2, but not CCL5/CCR5, mediates monocyte recruitment, inflammation and cartilage destruction in osteoarthritis. | Raghu, H., et al. 2017. Ann Rheum Dis. 76: 914-922. PMID: 27965260
- PI3K/Akt signaling pathway may be involved in MCP-1-induced P2X4R expression in cultured microglia and cancer-induced bone pain rats. | Yan, Y., et al. 2019. Neurosci Lett. 701: 100-105. PMID: 30776493
- Antifibrogenic effects of C-C chemokine receptor type 2 antagonist in a bleomycin-induced scleroderma model. | Ishikawa, M. and Yamamoto, T. 2021. Exp Dermatol. 30: 179-184. PMID: 32096250
- Recapitulating monocyte extravasation to the synovium in an organotypic microfluidic model of the articular joint. | Mondadori, C., et al. 2021. Biofabrication. 13: PMID: 34139683
- The roles of MCP-1/CCR2 mediated macrophage recruitment and polarization in bladder outlet obstruction (BOO) induced bladder remodeling. | Wang, W., et al. 2021. Int Immunopharmacol. 99: 107947. PMID: 34311189
Inhibitor of:
CKR-2B, and CKR-5.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
RS 504393, 10 mg | sc-204245 | 10 mg | $209.00 |