Molecular structure of RS 102221 hydrochloride
RS 102221 hydrochloride (CAS 185376-97-0)
Alternate Names:
4-dione hydrochloride; 8-[5-(2,4-Dimethoxy-5-(4-trifluoromethylphenylsulphonam ido)phenyl-5-oxopentyl]-1,3,8-triazaspiro[4.5]decane-2
Application:
RS 102221 hydrochloride is a selective SR-2C antagonist
CAS Number:
185376-97-0
Molecular Weight:
649.08
Molecular Formula:
C27H31F3N4O7S•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
RS 102221 hydrochloride is a selective SR-2C antagonist
RS 102221 hydrochloride (CAS 185376-97-0) References
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- Pharmacological characterization of an adenylyl cyclase-coupled 5-HT receptor in aplysia: comparison with mammalian 5-HT receptors. | Cohen, JE., et al. 2003. J Neurophysiol. 89: 1440-55. PMID: 12611939
- Human trabecular meshwork cells express functional serotonin-2A (5HT2A) receptors: role in IOP reduction. | Sharif, NA., et al. 2006. Invest Ophthalmol Vis Sci. 47: 4001-10. PMID: 16936116
- AL-34662: a potent, selective, and efficacious ocular hypotensive serotonin-2 receptor agonist. | Sharif, NA., et al. 2007. J Ocul Pharmacol Ther. 23: 1-13. PMID: 17341144
- Serotonin 5-hydroxytryptamine2C receptor signaling in hypothalamic proopiomelanocortin neurons: role in energy homeostasis in females. | Qiu, J., et al. 2007. Mol Pharmacol. 72: 885-96. PMID: 17622577
- The role of 5-HT2A and 5-HT2C receptors in the signal attenuation rat model of obsessive-compulsive disorder. | Flaisher-Grinberg, S., et al. 2008. Int J Neuropsychopharmacol. 11: 811-25. PMID: 18339223
- Raphé neurons stimulate respiratory circuit activity by multiple mechanisms via endogenously released serotonin and substance P. | Ptak, K., et al. 2009. J Neurosci. 29: 3720-37. PMID: 19321769
- 5-HT2C-like receptors in the brain of Xenopus laevis initiate sex-typical fictive vocalizations. | Yu, HJ. and Yamaguchi, A. 2009. J Neurophysiol. 102: 752-65. PMID: 19474172
- Selective serotonin receptor stimulation of the medial nucleus accumbens causes differential effects on food intake and locomotion. | Pratt, WE., et al. 2009. Behav Neurosci. 123: 1046-57. PMID: 19824770
- Serotonin neurones have anti-convulsant effects and reduce seizure-induced mortality. | Buchanan, GF., et al. 2014. J Physiol. 592: 4395-410. PMID: 25107926
- 5-HT2A receptor activation is necessary for CO2-induced arousal. | Buchanan, GF., et al. 2015. J Neurophysiol. 114: 233-43. PMID: 25925320
- The antifibrotic effects of alveolar macrophages 5-HT2C receptors blockade on bleomycin-induced pulmonary fibrosis in rats. | Elaidy, SM. and Essawy, SS. 2016. Pharmacol Rep. 68: 1244-1253. PMID: 27686964
- Effect of 5-HT2C receptor agonist and antagonist on chronic unpredictable stress (CUS) - Mediated anxiety and depression in adolescent Wistar albino rat: Implicating serotonin and mitochondrial ETC-I function in serotonergic neurotransmission. | Wankhar, W., et al. 2020. Behav Brain Res. 393: 112780. PMID: 32579979
- Serotonin 2C Antagonism in the Lateral Orbitofrontal Cortex Ameliorates Cue-Enhanced Risk Preference and Restores Sensitivity to Reinforcer Devaluation in Male Rats. | Hathaway, BA., et al. 2021. eNeuro. 8: PMID: 34815296
Activator of:
SR-2C.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
RS 102221 hydrochloride, 5 mg | sc-491403 | 5 mg | $194.00 | |||
RS 102221 hydrochloride, 25 mg | sc-491403A | 25 mg | $455.00 |