Molecular structure of RRD-251 hydrochloride, CAS Number: 72214-67-6
RRD-251 hydrochloride (CAS 72214-67-6)
Application:
RRD-251 hydrochloride is a reversible selective disruptor of Rb/Raf-1 interaction
CAS Number:
72214-67-6
Molecular Weight:
271.59
Molecular Formula:
C8H8Cl2N2S•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
RRD-251 hydrochloride is a reversible, potent, and selective disruptor of Rb/Raf-1 interaction. The retinoblastoma tumor suppressor protein (Rb) controls the G1-S boundary by repressing the transcriptional activity of the E2F family of transcription factors. Raf-1 kinase binds and phosphorylates Rb early in the G1 phase. RRD-251 significantly inhibits angiogenesis and tumor growth in vivo in an Rb-dependent manner. RRD-251 does not inhibit the binding of B-Raf to Rb and Raf-1 to Mek1/2. Also, RRD-251 does not affect the kinase activities associated with cyclin D, cyclin E, or Raf-1.
RRD-251 hydrochloride (CAS 72214-67-6) References
- RRD-251 enhances all-trans retinoic acid (RA)-induced differentiation of HL-60 myeloblastic leukemia cells. | Wallace, AS., et al. 2016. Oncotarget. 7: 46401-46418. PMID: 27331409
- GTSE1: a novel TEAD4-E2F1 target gene involved in cell protrusions formation in triple-negative breast cancer cell models. | Stelitano, D., et al. 2017. Oncotarget. 8: 67422-67438. PMID: 28978043
- The c-Raf modulator RRD-251 enhances nuclear c-Raf/GSK-3/VDR axis signaling and augments 1,25-dihydroxyvitamin D3-induced differentiation of HL-60 myeloblastic leukemia cells. | Supnick, HT., et al. 2018. Oncotarget. 9: 9808-9824. PMID: 29515772
Inhibitor of:
Rb.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
RRD-251 hydrochloride, 5 mg | sc-215822 | 5 mg | $35.00 | |||
RRD-251 hydrochloride, 25 mg | sc-215822A | 25 mg | $139.00 |