RP105 Antibody (MHR73): sc-52721

RP105 Antibody (MHR73) is a mouse monoclonal IgG1 antibody that detects RP105 in human samples through immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). RP105, a critical B-cell surface molecule, plays a vital role in transmitting growth-promoting signals that influence the life and death decisions of B cells, making RP105 essential for maintaining immune homeostasis. RP105 features tandem repeats of a leucine-rich motif in its extracellular domain, which facilitate important protein-protein interactions necessary for B cell activation and function. Notably, the amino acid sequence of human RP105 exhibits a high degree of homology with its mouse counterpart, sharing 74% identity, including the conserved leucine-rich motif. RP105 expression is significantly enhanced in the presence of MD1, although RP105 is specifically restricted to CD19-positive B cells, predominantly found on mature B cells located in the mantle zones, with minimal expression observed in germinal centers. This specificity underscores RP105′s importance in B cell biology and potential as a target for therapeutic interventions in B cell-related disorders. Anti-RP105 antibody (MHR73) is an invaluable tool for researchers investigating the complexities of B cell signaling and development.

The preferred RP105 antibody is RP105 Antibody (RP/14): sc-13592.