Molecular structure of Rp-8-Br-PET-cyclic GMPS, Sodium Salt, CAS Number: 172806-20-1
Rp-8-Br-PET-cyclic GMPS, Sodium Salt (CAS 172806-20-1)
Alternate Names:
β-Phenyl-1,N2-etheno-8-bromoguanosine-3′,5′-cyclic monophosphorothioate . sodium salt, Rp-isomer
Application:
Rp-8-Br-PET-cyclic GMPS, Sodium Salt is a competitive inhibitor of cGMP-dependent protein kinase (cGKI)
CAS Number:
172806-20-1
Purity:
≥99%
Molecular Weight:
562.3
Molecular Formula:
C18H14BrN5O6PS•Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Rp-8-Br-PET-cyclic GMPS, Sodium Salt is a metabolically-stable, competitive inhibitor of cGKI (cGKI alpha and beta). This compound blocks cGMP-gated retinal type ion channels (IC50 = 25 muM) and the activation of purified PKA type II (Ki = 10 muM). Rp-8-Br-PET-cyclic GMPS, Sodium Salt is more lipophilic and cell-permeable than Rp-8-pCPT-cGMPS. Note: 1 mumol = 0.56 mg. Rp-8-Br-PET-cyclic GMPS, Sodium Salt is an inhibitor of cGKII.
Rp-8-Br-PET-cyclic GMPS, Sodium Salt (CAS 172806-20-1) References
- Sodium nitroprusside activates potassium channels in the vena cava in normotensive but not in hypertensive rats. | Paulo, M., et al. 2013. Hypertens Res. 36: 765-9. PMID: 23784507
Inhibitor of:
cGKI alpha, cGKI beta, and cGKII.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Rp-8-Br-PET-cyclic GMPS, Sodium Salt, 1 µmol | sc-203989 | 1 µmol | $165.00 |