Rp-8-Br-PET-cGMPs CAS: 185246-32-6
MF: C18H14N5O6PSBr•Na
MW: 562.27
An inhibitor of cGKI and cGKII.

Rp-8-Br-PET-cGMPs (CAS 185246-32-6)

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Synonym: p-β-Phenyl-1,N2-etheno-8-bromoguanosine 3′,5′-cyclic monophosphorothioate sodium salt; Rp-8-Bromo-β-phenyl-1,N2-ethenoguanosine 3′,5′-cyclic monophosphorothioate sodium salt
Application: An inhibitor of cGKI and cGKII
CAS Number: 185246-32-6
Purity: ≥98%
Molecular Weight: 562.27
Molecular Formula: C18H14N5O6PSBr•Na
* Refer to Certificate of Analysis for lot specific data (including water content).
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Rp-8-Br-PET-cGMPS is metabolically stable, competitive inhibitor of cGKI (Ki = 30 nM) and cGKII (cGMP-dependent protein kinase G) and blocks cGMP-gated retinal type ion channels (IC50 = 25 μmol).


Ibarra-Alvarado, C., et al, Phosphorylation of blood vessel vasodilator-stimulated phosphoprotein at serine 239 as a functional biochemical marker of endothelial nitric oxide/cyclic GMP signaling. Mol. Pharmacol. 61, 312-319, (2002); Wei, J.Y., et al. , Identification of competitive antagonists of the rod photoreceptor cGMP-gated cation channel: beta-phenyl-1,N2-etheno-substituted cGMP analogues as probes of the cGMP-binding site. Biochemistry 35, 16815-16823, (1996)

Appearance :
Physical State :
Solubility :
Soluble in water (15 mg/ml at ≥ 60° C).
Storage :
Desiccate at -20° C
Melting Point :
240-300° C(lit.)
IC50 :
cGMP-gated retinal type ion channels: IC50 = 25 µM
Ki Data :
PKG I: Ki= 30 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
C1[[email protected]@H]2[[email protected]]([[email protected]]([[email protected]@H](O2)N3C4=C(C(=O)N5C=C(NC5=N4)C6=CC=CC=C6)N=C3Br)O)OP(=S)(O1)[O-].O.[Na+]

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Certificate of Analysis

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Rp-8-Br-PET-cGMPs  Product Citations

See how others have used Rp-8-Br-PET-cGMPs. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 27092079  2016. Front Pharmacol. 7: 86.

Citations 1 to 1 of 1 total

What is the solubility of this product?

Asked by: hawkeye11
Thank you for your question. Rp-8-Br-PET-cGMPs, sc-215820, should be soluble in water at 15mg/ml at a temperature of approximately 60 ºC or less.
Answered by: TechService7
Date published: 2017-01-12
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