Molecular structure of Rp-8-Br-PET-cGMPs, CAS Number: 185246-32-6
Rp-8-Br-PET-cGMPs (CAS 185246-32-6)
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Alternate Names:
p-β-Phenyl-1,N2-etheno-8-bromoguanosine 3′,5′-cyclic monophosphorothioate sodium salt; Rp-8-Bromo-β-phenyl-1,N2-ethenoguanosine 3′,5′-cyclic monophosphorothioate sodium salt
Application:
Rp-8-Br-PET-cGMPs is an inhibitor of cGKI and cGKII
CAS Number:
185246-32-6
Purity:
≥98%
Molecular Weight:
562.27
Molecular Formula:
C18H14N5O6PSBr•Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Rp-8-Br-PET-cGMPS is a potent and selective activator of cGMP-dependent protein kinase (PKG). Upon entering the cell, Rp-8-Br-PET-cGMPS binds to the regulatory domain of PKG, leading to a conformational change that activates the enzyme. This activation triggers a cascade of phosphorylation events, ultimately modulating the activity of various downstream targets involved in cellular signaling and regulation. Rp-8-Br-PET-cGMPS influences cellular processes by regulating ion channels, neurotransmitter release, smooth muscle relaxation, and gene expression. By modulating these pathways, Rp-8-Br-PET-cGMPS plays a role in mediating physiological responses such as vasodilation, neurotransmission, and smooth muscle relaxation. Rp-8-Br-PET-cGMPS is valuable for studying the role of cGMP-dependent signaling in cellular and molecular processes.
Rp-8-Br-PET-cGMPs (CAS 185246-32-6) References
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Inhibitor of:
cGKI, cGKII, DCST1, GC kinase, GCS-β-1, GCS-β-2, PKAα cat, sGC α1, sGC α2, sGC α2I, sGC β1, and sGC β2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Rp-8-Br-PET-cGMPs, 1 mg | sc-215820 | 1 mg | $343.00 | |||
Rp-8-Br-PET-cGMPs, 5 mg | sc-215820A | 5 mg | $1348.00 |