Molecular structure of Rp-8-Br-cAMPS, CAS Number: 129735-00-8
Rp-8-Br-cAMPS (CAS 129735-00-8)
See product citations (22)
Alternate Names:
Rp-8-Br-cAMPS also known as 8-Bromoadenosine 3′,5′-cyclic Monophosphothioate, Rp-Isomer . sodium salt
Application:
Rp-8-Br-cAMPS is a lipophilic membrane-permeable analog of the cAMP inhibitor Rp-cAMPS which functions by occupying cAMP binding sites
CAS Number:
129735-00-8
Purity:
≥98%
Molecular Weight:
446.15
Molecular Formula:
C10H10BrN5O5PS•Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Rp-8-Br-cAMPS is a lipophilic analog of Rp-cAMPS (sc-24010), demonstrating competitve preferential inhibition of PKA (PKC-alpha). Rp-8-Br-cAMPS is believed to function by occupying cAMP binding sites thus preventing dissociation and activation of the kinase holoenzyme. Rp-8-Br-cAMPS is resistant to mammalian cyclic nucleotide-dependent phosphodiesterases. Rp-8-Br-cAMPS is significantly more lipophilic and membrane permeant compared to Rp-cAMPS (sc-24010) or 8-Br-cAMP.
Rp-8-Br-cAMPS (CAS 129735-00-8) References
- Inhibition of cyclic guanosine 5'-monophosphate-dependent protein kinase I (PKG-I) in lumbar spinal cord reduces formalin-induced hyperalgesia and PKG upregulation. | Schmidtko, A., et al. 2003. Nitric Oxide. 8: 89-94. PMID: 12620371
- The negative immunoregulatory effects of fluoxetine in relation to the cAMP-dependent PKA pathway. | Maes, M., et al. 2005. Int Immunopharmacol. 5: 609-18. PMID: 15683856
- Polarization restricts hepatitis C virus entry into HepG2 hepatoma cells. | Mee, CJ., et al. 2009. J Virol. 83: 6211-21. PMID: 19357163
- An inhibitor of cAMP-dependent protein kinase induces behavioural and neurological antidepressant-like effects in rats. | Liebenberg, N., et al. 2011. Neurosci Lett. 498: 158-61. PMID: 21596096
- Protein kinase A antagonist inhibits β-catenin nuclear translocation, c-Myc and COX-2 expression and tumor promotion in Apc(Min/+) mice. | Brudvik, KW., et al. 2011. Mol Cancer. 10: 149. PMID: 22168384
- Dual contradictory roles of cAMP signaling pathways in hydroxyl radical production in the rat striatum. | Hara, S., et al. 2012. Free Radic Biol Med. 52: 1086-92. PMID: 22269608
- Cellular signalling pathways mediating dilation of porcine pial arterioles to adenosine A₂A receptor activation. | Hein, TW., et al. 2013. Cardiovasc Res. 99: 156-63. PMID: 23539502
- Off-target effect of the Epac agonist 8-pCPT-2'-O-Me-cAMP on P2Y12 receptors in blood platelets. | Herfindal, L., et al. 2013. Biochem Biophys Res Commun. 437: 603-8. PMID: 23850619
- Antiplatelet effects of caffeic acid due to Ca(2＋) mobilizationinhibition via cAMP-dependent inositol-1, 4, 5-trisphosphate receptor phosphorylation. | Lee, DH., et al. 2014. J Atheroscler Thromb. 21: 23-37. PMID: 24088646
- Extracellular NAD(+) inhibits human neutrophil apoptosis. | Pliyev, BK., et al. 2014. Apoptosis. 19: 581-93. PMID: 24292505
- Activation of intestinal CFTR Cl- channel by heat-stable enterotoxin and guanylin via cAMP-dependent protein kinase. | Chao, AC., et al. 1994. EMBO J. 13: 1065-72. PMID: 7510634
- Novel (Rp)-cAMPS analogs as tools for inhibition of cAMP-kinase in cell culture. Basal cAMP-kinase activity modulates interleukin-1 beta action. | Gjertsen, BT., et al. 1995. J Biol Chem. 270: 20599-607. PMID: 7657638
- Role of cyclic nucleotides in vasopressin-induced piglet pial artery dilation and opioid release. | Rossberg, MI. and Armstead, WM. 1997. Pediatr Res. 41: 498-504. PMID: 9098851
Inhibitor of:
A330050F15Rik, AKAP 100, AKAP 150, AKAP 2, EG433632, Esp23, PKA, PKAα cat, PKAβ cat, and Ser/Thr Protein Kinase.Activator of:
AKAP 82, MBNL2, TIS11D, and Torsin2A.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Rp-8-Br-cAMPS, 500 µg | sc-3539A | 500 µg | $250.00 | |||
Rp-8-Br-cAMPS, 1 mg | sc-3539 | 1 mg | $340.00 |