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RP 67580 is a potent and selective tachykinin NK-1R (NK1 receptor) antagonist. Displays higher affinity at rat and mouse than human receptors.
Garret et al (1991) Pharmacological properties of a potent and selective nonpeptide substance P antagonist. Proc.Natl.Acad.Sci.USA 88 10208. Fong et al (1992) Molecular basis for the species selectivity of the neurokinin-1 receptor antagonists CP-96,345 and RP67580. J.Biol.Chem. 267 25668. Beaujouan et al (1993) Higher potency of RP 67580, in the mouse and the rat compared with other nonpeptide and peptide tachykinin NK1 antagonists. Br.J.Pharmacol. 108 793. Rupniak et al (1993) Antinociceptive activity of NK1 receptor antagonists: non-specific effects of racemic RP67580. Br.J.Pharmacol. 110 1607.
See how others have used RP 67580. Click on the entry to view the PubMed entry .
PMID: # 25501647 2015. Archives of dermatological research. 307: 171-81.
PMID: # 24704373 Sakamoto, K. et al. 2014. Eur. J. Pharmacol. 733: 13-22.
PMID: # 23637859 2013. PloS one. 8: e61574.
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