Molecular structure of RP 67580, CAS Number: 135911-02-3
RP 67580 (CAS 135911-02-3)
See product citations (4)
Alternate Names:
(3aR,7aR)-Octahydro-2-[1-imino-2-(2-methoxyphenyl)ethyl]-7,7-diphenyl-4H-isoindol
Application:
RP 67580 is a selective antagonist of the tachykinin NK1 receptor
CAS Number:
135911-02-3
Purity:
≥97%
Molecular Weight:
438.57
Molecular Formula:
C29H30N2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
RP 67580 is a potent and selective tachykinin NK-1R (NK1 receptor) antagonist. Displays higher affinity at rat and mouse than human receptors.
RP 67580 (CAS 135911-02-3) References
Garret et al (1991) Pharmacological properties of a potent and selective nonpeptide substance P antagonist. Proc.Natl.Acad.Sci.USA 88 10208. Fong et al (1992) Molecular basis for the species selectivity of the neurokinin-1 receptor antagonists CP-96,345 and RP67580. J.Biol.Chem. 267 25668. Beaujouan et al (1993) Higher potency of RP 67580, in the mouse and the rat compared with other nonpeptide and peptide tachykinin NK1 antagonists. Br.J.Pharmacol. 108 793. Rupniak et al (1993) Antinociceptive activity of NK1 receptor antagonists: non-specific effects of racemic RP67580. Br.J.Pharmacol. 110 1607.Inhibitor of:
NK-1R, Preprotachykinin, PTα, and Tachykinin 4.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
RP 67580, 10 mg | sc-204894 | 10 mg | $219.00 | |||
| US: Only available in the US | ||||||
RP 67580, 50 mg | sc-204894A | 50 mg | $898.00 | |||
| US: Only available in the US | ||||||