Royal Jelly acid (CAS 14113-05-4)
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Royal Jelly acid is an unsaturated fatty acid that can be found in royal jelly produced from the hypopharyngeal and mandibular gland secretions of honeybees. Royal Jelly suppressed both VEGF-induced human umbilical vein endothelial cells (HUVECs) proliferation and migration. It has also been reported to stimulate the growth of glial cells and neural stem cells. The presence of the hydroxy group in its fatty acid chain is believed to be critical for its functional activities, making it a focal point for research into how such compounds interact with biological systems. Research into Royal Jelly acid and related compounds can offer insights into the chemical ecology of honey bees, including how they communicate, protect the hive, and manage the health and productivity of the colony. Understanding the biochemical pathways involved in the synthesis of Royal Jelly acid in bees might also open up new avenues for the biosynthesis of similar compounds in other organisms or in vitro systems.
Royal Jelly acid (CAS 14113-05-4) References
- Determination of (E)-10-hydroxy-2-decenoic acid content in pure royal jelly: a comparison between a new CZE method and HPLC. | Ferioli, F., et al. 2007. J Sep Sci. 30: 1061-9. PMID: 17566341
- Histone deacetylase inhibitor activity in royal jelly might facilitate caste switching in bees. | Spannhoff, A., et al. 2011. EMBO Rep. 12: 238-43. PMID: 21331099
- Royal jelly acid, 10-hydroxy-trans-2-decenoic acid, as a modulator of the innate immune responses. | Sugiyama, T., et al. 2012. Endocr Metab Immune Disord Drug Targets. 12: 368-76. PMID: 23061418
- Inhibitory mechanism of 10-hydroxy-trans-2-decenoic acid (royal jelly acid) against lipopolysaccharide- and interferon-β-induced nitric oxide production. | Sugiyama, T., et al. 2013. Inflammation. 36: 372-8. PMID: 23079939
- New synthesis of royal jelly acid. | Chiron, R. 1982. J Chem Ecol. 8: 709-13. PMID: 24415118
- Pheromones affecting ovary activation and ovariole loss in the Asian honey bee Apis cerana. | Tan, K., et al. 2015. J Insect Physiol. 74: 25-9. PMID: 25614964
- Effects of Pollen Feeding on Quality of Royal Jelly. | Pattamayutanon, P., et al. 2018. J Econ Entomol. 111: 2974-2978. PMID: 30184093
- Bioassay-guided isolation of active anti-adipogenic compound from royal jelly and the study of possible mechanisms. | Pandeya, PR., et al. 2019. BMC Complement Altern Med. 19: 33. PMID: 30696450
- 10-HDA Induces ROS-Mediated Apoptosis in A549 Human Lung Cancer Cells by Regulating the MAPK, STAT3, NF-κB, and TGF-β1 Signaling Pathways. | Lin, XM., et al. 2020. Biomed Res Int. 2020: 3042636. PMID: 33376719
- Royal jelly acid suppresses hepatocellular carcinoma tumorigenicity by inhibiting H3 histone lactylation at H3K9la and H3K14la sites. | Xu, H., et al. 2023. Phytomedicine. 118: 154940. PMID: 37453194
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Royal Jelly acid, 50 mg | sc-281143 | 50 mg | $77.00 | |||
Royal Jelly acid, 1 g | sc-281143A | 1 g | $306.00 |