Roxindole hydrochloride CAS: 112192-04-8
MF: C23H26N2O•HCl
MW: 382.93

Roxindole hydrochloride (CAS 112192-04-8)

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Alternate Names: 3-[4-(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl)butyl]-1H-indol-5-ol hydrochloride
Application: Roxindole hydrochloride is a selective and potent presynaptic D-2 dopamine autoreceptor agonist
CAS Number: 112192-04-8
Purity: ≥95%
Molecular Weight: 382.93
Molecular Formula: C23H26N2O•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
* Refer to Certificate of Analysis for lot specific data (including water content).

Roxindole hydrochloride is a selective and potent presynaptic D2DR (D2 dopamine autoreceptor) agonist. Roxindole inhibits serotonin (5-HT) uptake.


References

1. Seyfried, C.A., et al. 1989. Eur. J. Pharmacol. 160: 31-41.

Physical State :
Solid
Solubility :
Soluble in DMSO (50 mM with gentle warming).
Storage :
Desiccate at -20° C
Boiling Point :
575.7° C at 760 mmHg (Predicted)
Density :
1.17 g/cm3 (Predicted)
Refractive Index :
n20D 1.65 (Predicted)
IC50 :
D2DR: EC5050 = 0.37 nM (human); SR-1A: IC50 = 0.8 nM (human); Serotonin 1a (5-HT1a) receptor: IC50 = 0.8 nM (rat); Dopamine D2 receptor: IC50 = 5.6 nM (rat)
Ki Data :
D3DR: Ki= 0.4 nM (human); Dopamine D2 receptor: Ki= 0.88 nM (rat); D4DR: Ki= 24 nM (human); Dopamine D1 receptor: Ki= >10 µM (rat)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
PubChem CID :
MDL Number :
MFCD04038810
SMILES :
C1CN(CC=C1C2=CC=CC=C2)CCCCC3=CNC4=C3C=C(C=C4)O.Cl

Download SDS (MSDS)

Certificate of Analysis

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