Roxatidine (CAS 78273-80-0)
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Roxatidine is a competitive histamine H2-receptor antagonist. It functions by selectively blocking H2 receptors in the stomach, which inhibits the production of gastric acid. This action reduces the amount of acid in the stomach, leading to decreased acidity and pepsin content. Roxatidine′s mode of action involves binding to the H2 receptors on the basolateral membrane of the parietal cell, thereby preventing histamine from activating the adenylate cyclase enzyme. This ultimately results in decreased intracellular cyclic AMP levels, leading to reduced acid secretion by the parietal cells. Roxatidine may have a cytoprotective effect on the gastric mucosa, possibly through the enhancement of mucosal blood flow and the stimulation of prostaglandin synthesis. Roxatidine′s mechanism of action involves the inhibition of gastric acid secretion and potential cytoprotective effects on the gastric mucosa.
Roxatidine (CAS 78273-80-0) References
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Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Roxatidine, 1 mg | sc-280071A | 1 mg | $61.00 | |||
Roxatidine, 10 mg | sc-280071 | 10 mg | $459.00 |