Rotavirus virus p42 Antibody (1-O-15): sc-52435

Rotavirus virus p42 Antibody (1-O-15) is a mouse monoclonal IgG2a antibody that detects Rotavirus virus p42 of Rotavirus p42 origin by western blotting (WB) and immunofluorescence (IF). Anti-Rotavirus virus p42 antibody (1-O-15) is available as the non-conjugated form. Rotaviruses, which belong to the Reoviridae family, possess a unique structure characterized by a genome consisting of 11 double-stranded RNA segments encased in a distinctive three-layered icosahedral protein capsid. The p42 protein plays a crucial role in the virus′s ability to infect host cells, as p42 is involved in the assembly and stability of the viral capsid. This structural integrity is vital for the virus′s lifecycle, allowing p42 to effectively penetrate gastrointestinal epithelial cells, where p42 disrupts cellular membranes and alters calcium ion concentrations, ultimately leading to the symptoms associated with rotavirus infection, such as gastroenteritis. The p42 group-specific antigen is localized within the internal capsid, specifically in laminar crystalline structures found in both the nucleus and cytoplasm of infected cells. Understanding the function and importance of p42 protein is essential for developing targeted therapies and vaccines against rotavirus, which is a leading cause of severe diarrhea in children worldwide.

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Rotavirus virus p42 Antibody (1-O-15) References:

1. Relative localization of viroplasmic and endoplasmic reticulum-resident rotavirus proteins in infected cells.  |  González, RA., et al. 2000. Arch Virol. 145: 1963-73. PMID: 11043954
2. Immunization with baculovirus-expressed recombinant rotavirus proteins VP1, VP4, VP6, and VP7 induces CD8+ T lymphocytes that mediate clearance of chronic rotavirus infection in SCID mice.  |  Dharakul, T., et al. 1991. J Virol. 65: 5928-32. PMID: 1656079
3. Rotavirus proteins: structure and assembly.  |  Pesavento, JB., et al. 2006. Curr Top Microbiol Immunol. 309: 189-219. PMID: 16913048
4. [Molecular drift of rotavirus during attenuation].  |  Sergeev, VA., et al. 1987. Vopr Virusol. 32: 347-52. PMID: 2823483
5. Myristylation of rotavirus proteins.  |  Clark, B. and Desselberger, U. 1988. J Gen Virol. 69 (Pt 10): 2681-6. PMID: 2844975
6. Intracellular localization of rotaviral proteins.  |  Richardson, SC., et al. 1986. Arch Virol. 88: 251-64. PMID: 3010907
7. Preparation and characterization of antisera to electrophoretically purified SA11 virus polypeptides.  |  Bastardo, JW., et al. 1981. Infect Immun. 34: 641-7. PMID: 6174448
8. Identification of cytotoxic T cell epitopes on the VP3 and VP6 rotavirus proteins.  |  Franco, MA., et al. 1994. J Gen Virol. 75 (Pt 3): 589-96. PMID: 7510328
9. Homotypic and heterotypic serum neutralizing antibody response to rotavirus proteins following natural primary infection and reinfection in children.  |  Gorrell, RJ. and Bishop, RF. 1999. J Med Virol. 57: 204-11. PMID: 9892409

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Rotavirus virus p42 Antibody (1-O-15) has 0 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Rotavirus virus p42 Antibody (1-O-15) Specifications

Alternate Product Name: Rotavirus virus p42

Product Clone Name: 1-O-15

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a

Amino Acids:

Epitope Target: Rotavirus virus p42

Epitope Species: rotavirus

Product Reactivity/Detection: Rotavirus virus p42

Species Reactivity/Detection: Rotavirus p42

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IF

Vialing Information: Each vial contains 100 µg IgG_2a in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Rotavirus virus p42 Antibody (1-O-15): N/A