Molecular structure of Rosuvastatin Lactone, CAS Number: 503610-43-3
Rosuvastatin Lactone (CAS 503610-43-3)
Alternate Names:
Rosuvastatin-5S-lactone
Application:
Rosuvastatin Lactone is an intermediate in the production of Rosuvastatin derivatives
CAS Number:
503610-43-3
Molecular Weight:
463.52
Molecular Formula:
C22H26FN3O5S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Rosuvastatin Lactone is a research chemical primarily used as an analytical reference standard to study the metabolic fate of statin compounds. In the laboratory, it helps to understand the process of lactonization, which affects the mechanisms and stability of lactone-prone compounds. Analytical chemists employ this lactone form to calibrate and validate sophisticated equipment like LC-MS/MS, ensuring accurate measurement of similar compounds in complex biological matrices. Furthermore, it is used in the field of synthetic chemistry to explore the conversion pathways between the lactone form and its parent acid, providing insight into the interplay between different chemical species in a given environment.
Rosuvastatin Lactone (CAS 503610-43-3) References
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- Metabolic properties of the acid and lactone forms of HMG-CoA reductase inhibitors. | Fujino, H., et al. 2004. Xenobiotica. 34: 961-71. PMID: 15801541
- Influence of OATP1B1 genotype on the pharmacokinetics of rosuvastatin in Koreans. | Choi, JH., et al. 2008. Clin Pharmacol Ther. 83: 251-7. PMID: 17568401
- A New Improved RP-HPLC Method for Assay of Rosuvastatin Calcium in Tablets. | Kaila, HO., et al. 2010. Indian J Pharm Sci. 72: 592-8. PMID: 21694991
- Mechanism of the relaxant effect of rosuvastatin lactone on rat aortic rings. | Ana Cecilia, PP., et al. 2012. Front Biosci (Elite Ed). 4: 1787-94. PMID: 22201994
- Toxicity and bioconcentration of the pharmaceuticals moxifloxacin, rosuvastatin, and drospirenone to the unionid mussel Lampsilis siliquoidea. | Gilroy, EA., et al. 2014. Sci Total Environ. 487: 537-44. PMID: 24813769
- Statin Lactonization by Uridine 5'-Diphospho-glucuronosyltransferases (UGTs). | Schirris, TJ., et al. 2015. Mol Pharm. 12: 4048-55. PMID: 26412035
- Online monitoring of hepatic rat metabolism by coupling a liver biochip and a mass spectrometer. | Merlier, F., et al. 2017. Analyst. 142: 3747-3757. PMID: 28891561
- Simultaneous Determination of Rosuvastatin, Rosuvastatin-5 S-lactone, and N-desmethyl Rosuvastatin in Human Plasma by UPLC-MS/MS and Its Application to Clinical Study. | Bai, X., et al. 2018. Drug Res (Stuttg). 68: 328-334. PMID: 29232752
- Optimization of UPLC Method for Simultaneous Determination of Rosuvastatin and Rosuvastatin Degradation Products. | Zakrajšek, J., et al. 2017. Acta Chim Slov. 64: 968-979. PMID: 29318320
- Effects of SLCO1B1 and GATM gene variants on rosuvastatin-induced myopathy are unrelated to high plasma exposure of rosuvastatin and its metabolites. | Bai, X., et al. 2019. Acta Pharmacol Sin. 40: 492-499. PMID: 29950617
- Impact of SLCO1B1 Genetic Variation on Rosuvastatin Systemic Exposure in Pediatric Hypercholesterolemia. | Wagner, JB., et al. 2020. Clin Transl Sci. 13: 628-637. PMID: 31981411
- Assessing Transporter-Mediated Natural Product-Drug Interactions Via In vitro-In Vivo Extrapolation: Clinical Evaluation With a Probe Cocktail. | Nguyen, JT., et al. 2021. Clin Pharmacol Ther. 109: 1342-1352. PMID: 33174626
- Directly compressible formulation of immediate release rosuvastatin calcium tablets stabilized with tribasic calcium phosphate. | Zakowiecki, D., et al. 2022. Pharm Dev Technol. 27: 425-434. PMID: 35499305
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Rosuvastatin Lactone, 10 mg | sc-219993 | 10 mg | $360.00 |