ROS 234 dioxalate CAS: 184576-87-2
MF: C17H19N5O8
MW: 421.37
A potent H3 antagonist.

ROS 234 dioxalate (CAS 184576-87-2)

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Synonym: N-[3-(1H-Imidazol-4-yl)propyl]-1H-benzimidazol-2-amine dioxalate
Application: A potent H3 antagonist
CAS Number: 184576-87-2
Molecular Weight: 421.37
Molecular Formula: C17H19N5O8
* Refer to Certificate of Analysis for lot specific data (including water content).
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ROS 234 dioxalate is a potent H3 antagonist (pKB = 9.46 at guinea-pig ileum H3 receptors). This compound shows limited blood brain barrier permeability.


References

Ballabeni et al (2002) CNS access of selected H3-antagonists: ex vivo binding study in rats. Inflamm.Res. 51 Suppl.1 S55. Mor et al (2004) Synthesis, biological activity, QSAR and QSPR study of 2-aminobenzimidazole derivatives as potent H3-antagonists. Bioorg.Med.Chem.Lett. 12 663.

Physical State :
Solid
Solubility :
Soluble to 50 mM in Water and to 50 mM in DMSO
Storage :
Desiccate at room temperature
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
56972188
SMILES :
C1=CC=C2C(=C1)NC(=N2)NCCCC3=CN=CN3.C(=O)(C(=O)O)O.C(=O)(C(=O)O)O

Download SDS (MSDS)

Certificate of Analysis

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