RORα Antibody (C-7): sc-518081
- RORα Antibody (C-7) is a mouse monoclonal IgG3 RORα antibody, cited in 11 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 500-523 at the C-terminus of RORα1 of human origin
- ROR alpha Antibody (C-7) is recommended for detection of the multiple isoforms of ROR α receptors of human origin by WB, IP, IF and ELISA
- Anti-ROR alpha Antibody (C-7) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- TransCruz reagent for Gel Supershift and ChIP applications (sc-518081 X, 200 µg/0.1 ml)
- m-IgG3 BP-HRP is the preferred secondary detection reagent for RORα Antibody (C-7) for WB applications. This reagent is now offered in a bundle with RORα Antibody (C-7) (see ordering information below).
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RORα (C-7) is a mouse monoclonal IgG3 antibody that detects ROR alpha protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF) and enzyme-linked immunosorbent assay (ELISA). RORα (C-7) antibody is available as both non-conjugated form and multiple conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC) and multiple Alexa Fluor® conjugates. Retinoids are metabolites of vitamin A (retinol) and represent an important class of signaling molecule during vertebrate development and tissue differentiation. A large group of nuclear transcription factors, including vitamin D3 receptor (VDR), thyroid hormone receptor (TR), RAR, RXR and ecdysone receptor, have a high affinity for retinoic acids and are members of the steroid receptor superfamily. This family acts by directly associating with DNA sequences known as hormone response elements (HREs) and bind DNA as either homo- or heterodimers. RORα is a member of the steroid receptor superfamily and is classified as an "orphan receptor" due to the lack of a defined ligand. Two isoforms of RORα have been described and are designated RORα1 and RORα2. RORα, also referred to as RZR, binds DNA as a monomer at consensus RORα response elements (ROREs).
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
RORα Antibody (C-7) References:
- The Drosophila EcR gene encodes an ecdysone receptor, a new member of the steroid receptor superfamily. | Koelle, MR., et al. 1991. Cell. 67: 59-77. PMID: 1913820
- The CH25H-CYP7B1-RORα axis of cholesterol metabolism regulates osteoarthritis. | Choi, WS., et al. 2019. Nature. 566: 254-258. PMID: 30728500
- Melatonin ameliorates Parkinson's disease via regulating microglia polarization in a RORα-dependent pathway. | Li, J., et al. 2022. NPJ Parkinsons Dis. 8: 90. PMID: 35803929
- Transcription factor RORα enforces stability of the Th17 cell effector program by binding to a Rorc cis-regulatory element. | Hall, JA., et al. 2022. Immunity. 55: 2027-2043.e9. PMID: 36243007
- RORα-GABP-TFAM axis alleviates myosteatosis with fatty atrophy through reinforcement of mitochondrial capacity. | Kim, HJ., et al. 2024. J Cachexia Sarcopenia Muscle. 15: 615-630. PMID: 38272857
- RORα negatively regulates BCG-induced trained immunity. | Kilic, G., et al. 2024. Cell Immunol. 403-404: 104862. PMID: 39159505
- 9-cis retinoic acid signaling: changing partners causes some excitement. | Leblanc, BP. and Stunnenberg, HG. 1995. Genes Dev. 9: 1811-6. PMID: 7649469
- Determinants of target gene specificity for ROR alpha 1: monomeric DNA binding by an orphan nuclear receptor. | Giguère, V., et al. 1995. Mol Cell Biol. 15: 2517-26. PMID: 7739535
- Phosphorylation enhances the target gene sequence-dependent dimerization of thyroid hormone receptor with retinoid X receptor. | Bhat, MK., et al. 1994. Proc Natl Acad Sci U S A. 91: 7927-31. PMID: 8058736
- The nuclear receptor superfamily: the second decade. | Mangelsdorf, DJ., et al. 1995. Cell. 83: 835-9. PMID: 8521507
- The RXR heterodimers and orphan receptors. | Mangelsdorf, DJ. and Evans, RM. 1995. Cell. 83: 841-50. PMID: 8521508
- Identification of natural monomeric response elements of the nuclear receptor RZR/ROR. They also bind COUP-TF homodimers. | Schräder, M., et al. 1996. J Biol Chem. 271: 19732-6. PMID: 8702678
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
RORα Antibody (C-7) | sc-518081 | 200 µg/ml | $322.00 | |||
RORα Antibody (C-7): m-IgG3 BP-HRP Bundle | sc-551141 | 200 µg Ab; 40 µg BP | $361.00 | |||
RORα Antibody (C-7) X | sc-518081 X | 200 µg/0.1 ml | $322.00 | |||
RORα Antibody (C-7) AC | sc-518081 AC | 500 µg/ml, 25% agarose | $424.00 | |||
RORα Antibody (C-7) HRP | sc-518081 HRP | 200 µg/ml | $322.00 | |||
RORα Antibody (C-7) FITC | sc-518081 FITC | 200 µg/ml | $336.00 | |||
RORα Antibody (C-7) PE | sc-518081 PE | 200 µg/ml | $349.00 | |||
RORα Antibody (C-7) Alexa Fluor® 488 | sc-518081 AF488 | 200 µg/ml | $364.00 | |||
RORα Antibody (C-7) Alexa Fluor® 546 | sc-518081 AF546 | 200 µg/ml | $364.00 | |||
RORα Antibody (C-7) Alexa Fluor® 594 | sc-518081 AF594 | 200 µg/ml | $364.00 | |||
RORα Antibody (C-7) Alexa Fluor® 647 | sc-518081 AF647 | 200 µg/ml | $364.00 | |||
RORα Antibody (C-7) Alexa Fluor® 680 | sc-518081 AF680 | 200 µg/ml | $364.00 | |||
RORα Antibody (C-7) Alexa Fluor® 790 | sc-518081 AF790 | 200 µg/ml | $364.00 |