ROR2 Antibody (H-1): sc-374174

ROR2 Antibody (H-1) is a mouse monoclonal IgG1 kappa light chain antibody that detects ROR2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-ROR2 antibody (H-1) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. ROR2, also known as neurotrophic tyrosine kinase receptor-related 2 (NTRKR2), is a single-pass transmembrane tyrosine-protein kinase receptor that plays a crucial role in skeletal and endocrine development. ROR2 is primarily located in the cell membrane, where extracellular immunoglobulin-like domain, cysteine-rich domain, and kringle domain facilitate interactions with various ligands and signaling molecules. This localization is vital for promoting osteoblast differentiation and early chondrocyte formation, which are essential for proper cartilage and growth plate development. Additionally, ROR2 interacts with canonical Wnt1 and Wnt3, influencing their signaling pathways, and sequesters Dlxin-1, thereby affecting transcriptional activity of Msx-2. Defects in ROR2 are associated with significant skeletal disorders, including brachydactyly type B1 and Robinow syndrome, highlighting ROR2′s importance in maintaining skeletal integrity and function.

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ROR2 Antibody (H-1) References:

1. Recessive Robinow syndrome, allelic to dominant brachydactyly type B, is caused by mutation of ROR2.  |  Afzal, AR., et al. 2000. Nat Genet. 25: 419-22. PMID: 10932186
2. Distinct mutations in the receptor tyrosine kinase gene ROR2 cause brachydactyly type B.  |  Schwabe, GC., et al. 2000. Am J Hum Genet. 67: 822-31. PMID: 10986040
3. The receptor tyrosine kinase Ror2 associates with the melanoma-associated antigen (MAGE) family protein Dlxin-1 and regulates its intracellular distribution.  |  Matsuda, T., et al. 2003. J Biol Chem. 278: 29057-64. PMID: 12754255
4. One gene, two phenotypes: ROR2 mutations in autosomal recessive Robinow syndrome and autosomal dominant brachydactyly type B.  |  Afzal, AR. and Jeffery, S. 2003. Hum Mutat. 22: 1-11. PMID: 12815588
5. The receptor tyrosine kinase Ror2 is involved in non-canonical Wnt5a/JNK signalling pathway.  |  Oishi, I., et al. 2003. Genes Cells. 8: 645-54. PMID: 12839624
6. The orphan receptor tyrosine kinase Ror2 modulates canonical Wnt signaling in osteoblastic cells.  |  Billiard, J., et al. 2005. Mol Endocrinol. 19: 90-101. PMID: 15388793
7. Neurite extension in central neurons: a novel role for the receptor tyrosine kinases Ror1 and Ror2.  |  Paganoni, S. and Ferreira, A. 2005. J Cell Sci. 118: 433-46. PMID: 15654020
8. The orphan receptor tyrosine kinase Ror2 promotes osteoblast differentiation and enhances ex vivo bone formation.  |  Liu, Y., et al. 2007. Mol Endocrinol. 21: 376-87. PMID: 17095577
9. A new subtype of brachydactyly type B caused by point mutations in the bone morphogenetic protein antagonist NOGGIN.  |  Lehmann, K., et al. 2007. Am J Hum Genet. 81: 388-96. PMID: 17668388
10. ROR2 knockdown suppresses breast cancer growth through PI3K/ATK signaling.  |  Guo, M., et al. 2020. Aging (Albany NY). 12: 13115-13127. PMID: 32614787
11. miR-124-3p and miR-194-5p regulation of the PI3K/AKT pathway via ROR2 in medulloblastoma progression.  |  Wang, C., et al. 2024. Cancer Gene Ther. 31: 941-954. PMID: 38632356
12. ROR2 promotes invasion and chemoresistance of triple-negative breast cancer cells by activating PI3K/AKT/mTOR signaling.  |  DA, X., et al. 2024. Oncol Res. 32: 1209-1219. PMID: 38948021

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ROR2 Antibody (H-1) has 16 citations in a variety of scientific publications.

Primary antibodies like Anti-ROR2 Antibody (H-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ROR2 Antibody (H-1) Specifications

Alternate Product Name: ROR2

Product Clone Name: H-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 868-943

Epitope Target: ROR2

Epitope Species: human

Product Reactivity/Detection: ROR2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 16 citations in various scientific publications

Available Conjugates/Forms for ROR2 Antibody (H-1): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin