Roquefortine E (CAS 871982-52-4)
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Roquefortine E, also known as roquefortine C or cyclo(L-Pro-L-Val-L-Phe-D-Val-L-Val), is a cyclic peptide derived from the fungus Penicillium roqueforti. It serves as a natural preservative in cheese, offering unique properties that have garnered significant attention in the food industry and other sectors. Extensive research has been conducted to explore its potential applications. While the mechanism of action of Roquefortine E is not fully elucidated, it is believed to involve multiple pathways. Studies indicate that it disrupts the cell membranes of bacteria, fungi, and viruses, thus impeding their growth. Additionally, Roquefortine E has been found to inhibit enzymes involved in protein and nucleic acid synthesis, as well as enzymes participating in carbohydrate and lipid metabolism. It has further demonstrated inhibitory effects on enzymes engaged in the synthesis of cell wall components.
Roquefortine E (CAS 871982-52-4) References
- Roquefortine E, a diketopiperazine from an Australian isolate of Gymnoascus reessii. | Clark, B., et al. 2005. J Nat Prod. 68: 1661-4. PMID: 16309319
- Comparison of secondary metabolite production by Penicillium crustosum strains, isolated from Arctic and other various ecological niches. | Sonjak, S., et al. 2005. FEMS Microbiol Ecol. 53: 51-60. PMID: 16329929
- Polyenylpyrroles and polyenylfurans from an Australian Isolate of the soil ascomycete Gymnoascus reessii. | Clark, BR., et al. 2006. Org Lett. 8: 701-4. PMID: 16468746
- The total synthesis of roquefortine C and a rationale for the thermodynamic stability of isoroquefortine C over roquefortine C. | Shangguan, N., et al. 2008. J Am Chem Soc. 130: 6281-7. PMID: 18412344
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- Putative neuromycotoxicoses in an adult male following ingestion of moldy walnuts. | Botha, CJ., et al. 2019. Mycotoxin Res. 35: 9-16. PMID: 30088215
- Tyrosine Induced Metabolome Alterations of Penicillium roqueforti and Quantitation of Secondary Key Metabolites in Blue-Mold Cheese. | Hammerl, R., et al. 2019. J Agric Food Chem. 67: 8500-8509. PMID: 31298534
- Development and characterisation of a monoclonal antibody to detect the mycotoxin roquefortine C. | Maragos, CM. 2020. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 37: 1777-1790. PMID: 32730172
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Roquefortine E, 1 mg | sc-202324 | 1 mg | $155.00 |