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Roquefortine C is a mycotoxin produced by Penicillium roqueforti and P. crustosum. This compound has been noted to cause serious toxic effects in cell lines. In some experiments, Roquefortine C has been used as a biomarker for penitrem A intoxication. Studies suggest that G protein-mediated signaling is a key component of Roquefortine C production by Penicillium roqueforti. Further experiments report that Roquefortine C is potentially a neurotoxic compound that activates and inhibits detoxification enzymes Mdr (P-glycoprotein, P-gp) and CYP (cytochrome P450-3A), respectively.
1. Keblys, M., et al. 2004. Mycopathologia. 158: 317-324. PMID: 15702270
2. Bünger, J., et al. 2004. Toxicology. 202: 199-211. PMID: 15337583
3. Aninat, C., et al. 2005. Food Addit Contam. 22: 361-368. PMID: 16019806
4. García-Rico, R.O., et al. 2009. Int. Microbiol. 12: 123-129. PMID: 19784932
5. Tiwary, A.K., et al. 2009. J. Vet. Diagn. Invest. 21: 237-239. PMID: 19286504
See how others have used Roquefortine C. Click on the entry to view the PubMed entry .
PMID: # 25580944 Cakmakci, S. et al. 2015. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment. 32: 245-9.
PMID: # 23127715 Cakmakci, S. et al. 2012. Journal of food protection. 75: 2045-9.
PMID: # 15958659 Rand, TG. et al. 2005. Toxicol. Sci. 87: 213-222.
PMID: # 2730153 Frisvad, JC. et al. 1989 May-Jun. Arch. Environ. Contam. Toxicol. 18: 331-335.
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