Molecular structure of Ropinirole Hydrochloride, CAS Number: 91374-20-8
Ropinirole Hydrochloride (CAS 91374-20-8)
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Alternate Names:
4-[2-(Dipropylamino)ethyl]-1,3-dihydro-2H-indol-2-one hydrochloride; SKF 101468 hydrochloride
Application:
Ropinirole Hydrochloride is a dopamine receptor agonist
CAS Number:
91374-20-8
Purity:
≥99%
Molecular Weight:
296.84
Molecular Formula:
C16H24N2O•HCl
Supplemental Information:
This is as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Ropinirole Hydrochloride is a dopamine agonist that functions by activating dopamine receptors in the brain. It acts as a selective agonist at D2 and D3 dopamine receptors, leading to the stimulation of these receptors. This stimulation results in the modulation of neuronal activity in the brain, particularly in the areas associated with motor control and reward. By binding to and activating dopamine receptors, Ropinirole Hydrochloride influences the transmission of signals within the brain, ultimately impacting motor function and behavior. Its mode of action involves the direct interaction with dopamine receptors, leading to changes in neuronal activity and neurotransmitter release.
Ropinirole Hydrochloride (CAS 91374-20-8) References
- Ropinirole hydrochloride, a dopamine agonist. | Ravikumar, K. and Sridhar, B. 2006. Acta Crystallogr C. 62: o265-7. PMID: 16679599
- Development and evaluation of push-pull based osmotic delivery system for pramipexole. | Wakode, R., et al. 2008. PDA J Pharm Sci Technol. 62: 22-31. PMID: 18402365
- Formulation of intranasal mucoadhesive temperature-mediated in situ gel containing ropinirole and evaluation of brain targeting efficiency in rats. | Khan, S., et al. 2010. J Drug Target. 18: 223-34. PMID: 20030503
- Spectrophotometric estimation of ropinirole hydrochloride in tablets. | Shete, Y., et al. 2009. Indian J Pharm Sci. 71: 61-2. PMID: 20177460
- Sustained release microspheres of ropinirole hydrochloride: effect of process parameters. | Avachat, AM., et al. 2011. Acta Pharm. 61: 363-76. PMID: 22202196
- Controlled delivery of ropinirole hydrochloride through skin using modulated iontophoresis and microneedles. | Singh, ND. and Banga, AK. 2013. J Drug Target. 21: 354-66. PMID: 23311703
- Fabrication and statistical optimization of surface engineered PLGA nanoparticles for naso-brain delivery of ropinirole hydrochloride: in-vitro-ex-vivo studies. | Patil, GB. and Surana, SJ. 2013. J Biomater Sci Polym Ed. 24: 1740-56. PMID: 23705812
- HPLC-UV method development and validation for the quantification of ropinirole in new PLGA multiparticulate systems: Microspheres and nanoparticles. | Fuster, J., et al. 2015. Int J Pharm. 491: 310-7. PMID: 26149934
- PLGA/DPPC/trimethylchitosan spray-dried microparticles for the nasal delivery of ropinirole hydrochloride: in vitro, ex vivo and cytocompatibility assessment. | Karavasili, C., et al. 2016. Mater Sci Eng C Mater Biol Appl. 59: 1053-1062. PMID: 26652464
- Ex vivo buccal drug delivery of ropinirole hydrochloride in the presence of permeation enhancers: the effect of charge. | Kontogiannidou, E., et al. 2017. Pharm Dev Technol. 22: 1017-1021. PMID: 26794504
- Application of chemometric approach for development and validation of high performance liquid chromatography method for estimation of ropinirole hydrochloride. | Fatima, S., et al. 2019. J Sep Sci. 42: 3293-3301. PMID: 31465611
- Chitosan-coated PLGA nanoparticles for the nasal delivery of ropinirole hydrochloride: In vitro and ex vivo evaluation of efficacy and safety. | Chatzitaki, AT., et al. 2020. Int J Pharm. 589: 119776. PMID: 32818538
- Clinical Observation of Ropinirole Hydrochloride in the Treatment of Parkinson's Disease. | Zhang, J., et al. 2022. Comput Math Methods Med. 2022: 3989770. PMID: 35341012
Inhibitor of:
PLP-A, Prolactin, and Thyrotropin-releasing hormone (TRH).Activator of:
D2, D2DR, D3DR, D5DR, GPR52, GRIN3, GRK 6, and VAMP-1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ropinirole Hydrochloride, 25 mg | sc-205843 | 25 mg | $82.00 | |||
Ropinirole Hydrochloride, 100 mg | sc-205843A | 100 mg | $311.00 |