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Rocuronium bromide (CAS 119302-91-9)

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Alternate Names:
Zemuron; Esmeron; Eslax
Application:
Rocuronium bromide is a non-depolarizing neuromuscular blocker used in anesthesia to help insert breathing tubes
CAS Number:
119302-91-9
Purity:
≥99%
Molecular Weight:
609.68
Molecular Formula:
C32H53BrN2O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Rocuronium bromide is a non-depolarizing neuromuscular blocking agent that functions by competitively binding to the nicotinic acetylcholine receptor at the motor endplate. This binding prevents the action of acetylcholine, leading to inhibition of neuromuscular transmission. Rocuronium bromide blocks the transmission of nerve impulses to the muscle, resulting in muscle relaxation and paralysis. This chemical′s mechanism of action involves interfering with the normal physiological communication between the nerve and muscle, ultimately leading to the temporary loss of muscle function. By disrupting the neuromuscular junction, Rocuronium bromide effectively prevents the initiation and propagation of muscle contractions, making it a useful tool for studying neuromuscular physiology and pharmacology in experimental applications.


Rocuronium bromide (CAS 119302-91-9) References

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  2. [An overview of the pharmacokinetics and pharmacodynamics of rocuronium bromide].  |  Iwasaki, H. 2006. Masui. 55: 826-33. PMID: 16856542
  3. Pharmacological and non-pharmacological interventions for reducing rocuronium bromide induced pain on injection in children and adults.  |  Prabhakar, H., et al. 2016. Cochrane Database Syst Rev. 2: CD009346. PMID: 26871982
  4. Rocuronium Bromide Inhibits Inflammation and Pain by Suppressing Nitric Oxide Production and Enhancing Prostaglandin E2 Synthesis in Endothelial Cells.  |  Baek, SB., et al. 2016. Int Neurourol J. 20: 296-303. PMID: 28043117
  5. Rocuronium bromide: clinical application of single-dose pharmacokinetic models to continuous infusion.  |  Oda, Y. 2018. J Anesth. 32: 1-2. PMID: 28828750
  6. Potentiation of Rocuronium Bromide by Lithium Carbonate: A Case Report.  |  Kishimoto, N., et al. 2020. Anesth Prog. 67: 146-150. PMID: 32992336
  7. Efficacy of topical rocuronium bromide as a mydriatic agent in domestic pigeons (Columba livia).  |  Susanti, L., et al. 2021. J Vet Med Sci. 83: 501-506. PMID: 33612658
  8. The safety of high-dose rocuronium bromide in general anesthesia for spinal surgery and its effects on muscle relaxation.  |  Yuan, H., et al. 2021. Am J Transl Res. 13: 8110-8117. PMID: 34377294
  9. Rocuronium bromide suppresses esophageal cancer via blocking the secretion of C-X-C motif chemokine ligand 12 from cancer associated fibroblasts.  |  Li, J., et al. 2023. J Transl Med. 21: 248. PMID: 37029408
  10. Comparison of rocuronium, succinylcholine, and vecuronium for rapid-sequence induction of anesthesia in adult patients.  |  Magorian, T., et al. 1993. Anesthesiology. 79: 913-8. PMID: 7902034
  11. Interactions of volatile anaesthetics with rocuronium bromide in perspective.  |  Agoston, S. 1994. Eur J Anaesthesiol Suppl. 9: 107-11. PMID: 7925200
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  13. Clinical pharmacokinetics of rocuronium bromide.  |  Khuenl-Brady, KS. and Sparr, H. 1996. Clin Pharmacokinet. 31: 174-83. PMID: 8877248

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Rocuronium bromide, 10 mg

sc-204892
10 mg
$60.00

Rocuronium bromide, 25 mg

sc-204892A
25 mg
$103.00