Molecular structure of Rocaglamide C, CAS Number: 189322-67-6
Rocaglamide C (CAS 189322-67-6)
Application:
Rocaglamide C is a derivative of Rocaglamide
CAS Number:
189322-67-6
Molecular Weight:
521.6
Molecular Formula:
C29H31NO8
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Rocaglamide C is a derivative of Rocaglamide (sc-203241) with similar properties. The compound has been observed to have an apoptotic effect on leukemic cells through the mitochondrial pathway. Through differential regulation of FLIPS/L (c-FLIP) and FAS-L expression the compound has been documented to promote activation induced cell death in leukemic T cells through the JNK activation as well as inhibition of NF-κB activation in non-leukemic T cells. Rocaglamide C also retains insecticide activity towards the larvae Spodoptera littoralis (0.8 to 80 ppm).
Rocaglamide C (CAS 189322-67-6) References
- Insecticidal rocaglamide derivatives from Aglaia spectabilis (Meliaceae). | Schneider, C., et al. 2000. Phytochemistry. 54: 731-6. PMID: 11014256
- New insecticidal rocaglamide derivatives and related compounds from Aglaia oligophylla. | Dreyer, M., et al. 2001. J Nat Prod. 64: 415-20. PMID: 11325219
- Rocaglamides, glycosides, and putrescine bisamides from Aglaia dasyclada. | Chaidir,., et al. 2001. J Nat Prod. 64: 1216-20. PMID: 11575959
- Rocaglamide derivatives are potent inhibitors of NF-kappa B activation in T-cells. | Baumann, B., et al. 2002. J Biol Chem. 277: 44791-800. PMID: 12237314
- Rocaglamide derivatives are immunosuppressive phytochemicals that target NF-AT activity in T cells. | Proksch, P., et al. 2005. J Immunol. 174: 7075-84. PMID: 15905551
- Potential of cyclopenta[b]benzofurans from Aglaia species in cancer chemotherapy. | Kim, S., et al. 2006. Anticancer Agents Med Chem. 6: 319-45. PMID: 16842234
- Potent cytotoxic rocaglamide derivatives from the fruits of Amoora cucullata. | Chumkaew, P., et al. 2006. Chem Pharm Bull (Tokyo). 54: 1344-6. PMID: 16946551
- Rocaglamide sensitizes leukemic T cells to activation-induced cell death by differential regulation of CD95L and c-FLIP expression. | Zhu, JY., et al. 2009. Cell Death Differ. 16: 1289-99. PMID: 19373244
- Two new lignans from twigs of Aglaia odorata. | Peng, L., et al. 2016. J Asian Nat Prod Res. 18: 147-52. PMID: 26207974
- New insecticidal rocaglamide derivatives from flowers of Aglaia duperreana (Meliaceae). | Hiort, J., et al. 1999. Phytochemistry. 52.5: 837-842.
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NVL.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Rocaglamide C, 50 µg | sc-202793 | 50 µg | $109.00 |