robo1 Antibody (2G6): sc-293444
- robo1 Antibody (2G6) is a mouse monoclonal IgG2a κ robo1 antibody, cited in 3 publications, provided at 100 µg/ml
- raised against a recombinant protein mapping within amino acids 491-589 representing partial length robo1 of human origin
- recommended for detection of robo1 of mouse, rat and human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for robo1 Antibody (2G6). This work is in progress.
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robo1 Antibody (2G6) is a mouse monoclonal IgG2a kappa light chain antibody that detects robo1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). robo1 (2G6) antibody is available as a non-conjugated format. robo1 protein plays a crucial role in central nervous system development by acting as an axon guidance receptor, essential for directing neuronal axon growth during embryonic development. Specifically, robo1 interacts with Slit repellent protein, helping prevent axons from crossing the nervous system midline, ensuring proper neuronal wiring. This interaction maintains neural circuit organization by establishing distinct left and right pathways in the spinal cord and brain. robo1 expression regulation is critical; non-crossing axons exhibit high robo1 levels, while crossing axons show decreased expression before crossing and increased expression afterward. This dynamic expression pattern enables precise axon navigation and maintains nervous system integrity. robo1 facilitates these important processes as a key player in neural development, with implications for understanding various neurological disorders.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
robo1 Antibody (2G6) References:
- The middle and the end: slit brings guidance and branching together in axon pathway selection. | Van Vactor, D. and Flanagan, JG. 1999. Neuron. 22: 649-52. PMID: 10230784
- astray, a zebrafish roundabout homolog required for retinal axon guidance. | Fricke, C., et al. 2001. Science. 292: 507-10. PMID: 11313496
- Activation of Slit2-Robo1 signaling promotes liver fibrosis. | Chang, J., et al. 2015. J Hepatol. 63: 1413-20. PMID: 26264936
- SLIT2/ROBO1-signaling inhibits macropinocytosis by opposing cortical cytoskeletal remodeling. | Bhosle, VK., et al. 2020. Nat Commun. 11: 4112. PMID: 32807784
- Coadaptation fostered by the SLIT2-ROBO1 axis facilitates liver metastasis of pancreatic ductal adenocarcinoma. | Li, Q., et al. 2023. Nat Commun. 14: 861. PMID: 36792623
- SLIT2/ROBO1 signaling suppresses mTORC1 for organelle control and bacterial killing. | Bhosle, VK., et al. 2023. Life Sci Alliance. 6: PMID: 37311584
- Recombinant Slit2 suppresses neuroinflammation and Cdc42-mediated brain infiltration of peripheral immune cells via Robo1-srGAP1 pathway in a rat model of germinal matrix hemorrhage. | Li, Q., et al. 2023. J Neuroinflammation. 20: 249. PMID: 37899442
- ROBO1 deficiency impairs HSPC homeostasis and erythropoiesis via CDC42 and predicts poor prognosis in MDS. | Jin, JC., et al. 2023. Sci Adv. 9: eadi7375. PMID: 38019913
- Stromal Cell-SLIT3/Cardiomyocyte-ROBO1 Axis Regulates Pressure Overload-Induced Cardiac Hypertrophy. | Liu, X., et al. 2024. Circ Res. 134: 913-930. PMID: 38414132
- Targeting axonal guidance dependencies in glioblastoma with ROBO1 CAR T cells. | Chokshi, CR., et al. 2024. Nat Med. 30: 2936-2946. PMID: 39095594
- Roundabout controls axon crossing of the CNS midline and defines a novel subfamily of evolutionarily conserved guidance receptors. | Kidd, T., et al. 1998. Cell. 92: 205-15. PMID: 9458045
- The conserved immunoglobulin superfamily member SAX-3/Robo directs multiple aspects of axon guidance in C. elegans. | Zallen, JA., et al. 1998. Cell. 92: 217-27. PMID: 9458046
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
robo1 Antibody (2G6) | sc-293444 | 100 µg/ml | $316.00 |