Date published: 2025-10-3

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Robenidine Hydrochloride (CAS 25875-50-7)

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CAS Number:
25875-50-7
Molecular Weight:
370.66
Molecular Formula:
C15H13Cl2N5•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Robenidine hydrochloride, also referred to as 1,3-di(4-chlorophenyl)guanidine hydrochloride, is an organic compound. Robenidine hydrochloride has promise in both in vivo and in vitro experiments, making it useful for scientific applications. When utilized in laboratory experiments, robenidine hydrochloride exhibits several advantages over alternative compounds. Robenidine hydrochloride is hypothesized to function by inhibiting the enzyme monoamine oxidase (MAO), responsible for the degradation of monoamine neurotransmitters like serotonin and dopamine. By impeding MAO, levels of these neurotransmitters increase.


Robenidine Hydrochloride (CAS 25875-50-7) References

  1. Automated high-pressure liquid chromatographic assay of robenidine hydrochloride.  |  Zagar, JB., et al. 1975. J Assoc Off Anal Chem. 58: 822-7. PMID: 1150616
  2. Inhibitory effects of 19 antiprotozoal drugs and antibiotics on Babesia microti infection in BALB/c mice.  |  Yao, JM., et al. 2015. J Infect Dev Ctries. 9: 1004-10. PMID: 26409742
  3. Safety and efficacy of microorganism DSM 11798 as a technological additive for all avian species.  |  , ., et al. 2017. EFSA J. 15: e04676. PMID: 32625266
  4. Safety and efficacy of Alterion NE® (Bacillus subtilis DSM 29784) as a feed additive for minor poultry species for fattening and reared for laying.  |  , ., et al. 2018. EFSA J. 16: e05204. PMID: 32625838
  5. Safety and efficacy of Robenz® 66G (robenidine hydrochloride) for chickens for fattening and turkeys for fattening.  |  , ., et al. 2019. EFSA J. 17: e05613. PMID: 32626244
  6. Safety and efficacy of TechnoSpore® (Bacillus coagulans DSM 32016) for piglets, other growing Suidae, chickens for fattening, other poultry for fattening and ornamental birds.  |  , ., et al. 2020. EFSA J. 18: e06158. PMID: 32874333
  7. Determination of robenidine in shrimp and chicken samples using the indirect competitive enzyme-linked immunosorbent assay and immunochromatographic strip assay.  |  Lin, L., et al. 2021. Analyst. 146: 721-729. PMID: 33231576
  8. Assessment of the feed additive consisting of Enterococcus faeciumDSM 7134 (Bonvital®) for chickens for fattening for the renewal of its authorisation (Lactosan GmbH & Co. KG).  |  , ., et al. 2021. EFSA J. 19: e06451. PMID: 33732397
  9. Safety and efficacy of an additive consisting of Bacillus subtilis DSM 32325 for all animal species (Chr. Hansen A/S).  |  , ., et al. 2021. EFSA J. 19: e06524. PMID: 33897863
  10. Optimization of an Evaluation Method for Anti-Babesia microti Drug Efficacy.  |  Yin, M., et al. 2022. Acta Trop. 225: 106179. PMID: 34627758
  11. Safety and efficacy of a feed additive consisting of Bacillus subtilis FERM BP-07462, Enterococcus lactis FERM BP-10867 and Clostridium butyricum FERM BP-10866 (BIO-THREE®) for chickens for fattening, chickens reared for laying, turkeys for fattening, turkeys reared for breeding, all avian species for rearing/fattening to slaughter and all avian species reared for laying or breeding to point of lay (TOA BIOPHARMA Co., Ltd.).  |  , ., et al. 2022. EFSA J. 20: e07342. PMID: 35757152
  12. Assessment of the feed additive consisting of robenidine hydrochloride (Cycostat® 66G) for rabbits for breeding and rabbits for fattening for the renewal of its authorisation (Zoetis).  |  , ., et al. 2023. EFSA J. 21: e07863. PMID: 36908564
  13. Absorption, excretion, and metabolism of robenz, robenidine hydrochloride (1,3-bis(p-chlorobenzylideneamino)guanidine hydrochloride), in the rat.  |  Zulalian, J. and Gatterdam, PE. 1973. J Agric Food Chem. 21: 794-7. PMID: 4733370

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Robenidine Hydrochloride, 10 g

sc-212788
10 g
$250.00