Robenacoxib (CAS 220991-32-2)
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Robenacoxib is a compound that has gained interest in the biochemical study of enzyme inhibition, specifically targeting the cyclooxygenase-2 (COX-2) enzyme. It is used to investigate the structure-activity relationships of COX-2 inhibitors, which are key to understanding the enzyme′s role in the inflammatory response at a molecular level. In research environments, Robenacoxib is employed to examine the selective inhibition of COX-2 compared to COX-1, which is important for discerning the pathways involved in inflammation and pain. Studies utilizing Robenacoxib often focus on the biochemical pathways of prostaglandin synthesis and the regulatory mechanisms behind them. Additionally, the compound′s interactions with various biomolecules are explored to elucidate its selectivity and binding affinity, which contributes to the field of molecular pharmacology.
Robenacoxib (CAS 220991-32-2) References
- Preclinical pharmacology of robenacoxib: a novel selective inhibitor of cyclooxygenase-2. | King, JN., et al. 2009. J Vet Pharmacol Ther. 32: 1-17. PMID: 19161451
- Sparing effect of robenacoxib on the minimum alveolar concentration for blunting adrenergic response (MAC-BAR) of sevoflurane in dogs. | Tamura, J., et al. 2014. J Vet Med Sci. 76: 113-7. PMID: 24004933
- Robenacoxib versus meloxicam for the control of peri-operative pain and inflammation associated with orthopaedic surgery in cats: a randomised clinical trial. | Speranza, C., et al. 2015. BMC Vet Res. 11: 79. PMID: 25880535
- Effect of benazepril, robenacoxib and their combination on glomerular filtration rate in cats. | King, JN., et al. 2016. BMC Vet Res. 12: 124. PMID: 27338786
- Efficacy and safety of oral robenacoxib (tablet) for the treatment of pain associated with soft tissue surgery in client-owned dogs. | Friton, G., et al. 2017. BMC Vet Res. 13: 197. PMID: 28651573
- Analgesic Efficacy and Hematologic Effects of Robenacoxib in Mice. | Beninson, JA., et al. 2018. J Am Assoc Lab Anim Sci. 57: 258-267. PMID: 29784076
- Six-month safety evaluation of robenacoxib tablets (Onsior™) in dogs after daily oral administrations. | Toutain, CE., et al. 2018. BMC Vet Res. 14: 242. PMID: 30119677
- Robenacoxib in the treatment of pain in cats and dogs: safety, efficacy, and place in therapy. | Kongara, K. and Chambers, JP. 2018. Vet Med (Auckl). 9: 53-61. PMID: 30148083
- Safety evaluation of the interchangeable use of robenacoxib in commercially-available tablets and solution for injection in cats. | Heit, MC., et al. 2020. BMC Vet Res. 16: 355. PMID: 32988403
- Robenacoxib shows efficacy for the treatment of chronic degenerative joint disease-associated pain in cats: a randomized and blinded pilot clinical trial. | Adrian, D., et al. 2021. Sci Rep. 11: 7721. PMID: 33833276
- PHARMACOKINETIC, PHARMACODYNAMIC, AND TOXICOLOGY STUDY OF ROBENACOXIB IN RAINBOW TROUT (ONCORHYNCHUS MYKISS). | Raulic, J., et al. 2021. J Zoo Wildl Med. 52: 529-537. PMID: 34130395
- Clinical safety of robenacoxib in cats with chronic musculoskeletal disease. | King, JN., et al. 2021. J Vet Intern Med. 35: 2384-2394. PMID: 34196973
- Robenacoxib pharmacokinetics in sheep following oral, subcutaneous, and intravenous administration. | Fadel, C., et al. 2022. J Vet Pharmacol Ther. 45: 550-557. PMID: 35899473
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Robenacoxib, 100 mg | sc-391707 | 100 mg | $265.00 |