Molecular structure of RO1138452, CAS Number: 221529-58-4
RO1138452 (CAS 221529-58-4)
Alternate Names:
4, 5-dihydro-N-[4-[[4-(1-methylethoxy)phenyl]methyl]phenyl]-1H-imadazol-2-amine
Application:
RO1138452 is an IP receptor antagonist
CAS Number:
221529-58-4
Molecular Weight:
309.4
Molecular Formula:
C19H23N3O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
RO1138452 is one of the more potent high-affinity ligands and functional antagonists for the human IP (prostacyclin) receptor (1). It antagonizes the carbaprostacyclin-induced activation of human neuroblastoma adenylate cyclase, blocking the accumulation of cyclic AMP in a dose-dependent manner. It also inhibits the binding of tritiated iloprost to rodent neuroblastoma cells with a Ki of approximately 1.5 nM. At levels between 2-20 mg/kg in rats, RO1138452 shows significant analgesic activity in standard antinociceptive assays (1).
RO1138452 (CAS 221529-58-4) References
1 Clark, R.D., Jahangir, A., Severance, D., et al. Discovery and SAR development of 2-(phenylamino) imidazolines as prostacyclin receptor antagonists. Bioorg Medicinal Chem Letters 14 1053-1056 (2004).Inhibitor of:
IP Receptor.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
RO1138452, 1 mg | sc-222261 | 1 mg | $106.00 | |||
RO1138452, 5 mg | sc-222261A | 5 mg | $480.00 |