Ro 41-5253 (CAS 144092-31-9)
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Application:
Ro 41-5253 is Ro 41-5253 is an inhibitor of RAR α.
CAS Number:
144092-31-9
Molecular Weight:
484.7
Molecular Formula:
C28H36O5S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Ro 41-5253 functions as a potent and selective inhibitor of human immunodeficiency virus type 1 (HIV-1) protease. It exerts its mechanism of action by binding to the active site of the HIV-1 protease enzyme, thereby preventing the cleavage of viral polyproteins into functional proteins for viral replication. This inhibition ultimately disrupts the maturation of new viral particles, leading to the production of non-infectious progeny virions.
Ro 41-5253 (CAS 144092-31-9) References
- Retinoids in lung cancer chemoprevention and treatment. | Toma, S., et al. 1999. Ann Oncol. 10 Suppl 5: S95-102. PMID: 10582149
- Retinoids and malignant melanoma: a pathway of proliferation inhibition on SK MEL28 cell line. | Emionite, L., et al. 2003. Anticancer Res. 23: 13-9. PMID: 12680189
- Histone deacetylase inhibitors enhance retinoid response in human breast cancer cell lines. | Emionite, L., et al. 2004. Anticancer Res. 24: 4019-24. PMID: 15736447
- Cancer prevention by retinoids and carotenoids: independent action on a common target. | Bertram, JS. and Vine, AL. 2005. Biochim Biophys Acta. 1740: 170-8. PMID: 15949684
- Upregulation of connexin 43 by retinoids but not by non-provitamin A carotenoids requires RARs. | Vine, AL. and Bertram, JS. 2005. Nutr Cancer. 52: 105-13. PMID: 16091010
- A widely used retinoic acid receptor antagonist induces peroxisome proliferator-activated receptor-gamma activity. | Schupp, M., et al. 2007. Mol Pharmacol. 71: 1251-7. PMID: 17290005
- Retinoic acid signaling biomarkers after treatment with retinoic acid and retinoic acid receptor alpha antagonist (Ro 41-5253) in canine testis: an in vitro organ culture study. | Kasimanickam, VR. and Kasimanickam, RK. 2013. Theriogenology. 79: 10-6. PMID: 23102850
- Effect of all-trans-retinoic acid on enterovirus 71 infection in vitro. | Chen, S., et al. 2014. Br J Nutr. 111: 1586-93. PMID: 24495389
- All-Trans Retinoic Acid Increases Aquaporin 3 Expression in Human Vaginal Epithelial Cells. | Lee, HS., et al. 2016. Sex Med. 4: e249-e254. PMID: 27461974
- ATRA Signaling Regulates the Expression of COL9A1 through BMP2-WNT4-RUNX1 Pathway in Antler Chondrocytes. | Zhang, HL., et al. 2017. J Exp Zool B Mol Dev Evol. 328: 575-586. PMID: 28643469
- Ro41-5253, a selective antagonist of retinoic acid receptor α, ameliorates chronic unpredictable mild stress-induced depressive-like behaviors in rats: Involvement of regulating HPA axis and improving hippocampal neuronal deficits. | Ke, Q., et al. 2019. Brain Res Bull. 146: 302-309. PMID: 30711623
- Regulation of RXR-RAR Heterodimers by RXR- and RAR-Specific Ligands and Their Combinations. | le Maire, A., et al. 2019. Cells. 8: PMID: 31694317
- RARalpha antagonist Ro 41-5253 inhibits proliferation and induces apoptosis in breast-cancer cell lines. | Toma, S., et al. 1998. Int J Cancer. 78: 86-94. PMID: 9724098
Inhibitor of:
COMT.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ro 41-5253, 5 mg | sc-471345 | 5 mg | $109.00 |