Molecular structure of Ro 4-1284, CAS Number: 303-75-3
Ro 4-1284 (CAS 303-75-3)
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Alternate Names:
2-Hydroxy-2-ethyl-3-isobutyl-9,10-dimethoxy-1,2,3,4,5,6,7-hexahydrobenzo[a]chinolizine
CAS Number:
303-75-3
Molecular Weight:
347.49
Molecular Formula:
C21H33NO3
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
A reversible VMAT2 inhibitor. Proposed catecholamine depletor. Also a P-glycoprotein (P-GP) inhibitor. Researchers might explore its interactions with various substrates or its role as a building block in the synthesis of complex polymers. The structural characteristics of Ro 4-1284 could influence polymerization reactions or affect the physical properties of the resulting materials, such as elasticity, durability, or resistance to environmental stressors. In the realm of analytical chemistry, Ro 4-1284 might serve as a reference compound in the development of new analytical methods or in the calibration of analytical instruments.
Ro 4-1284 (CAS 303-75-3) References
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- Modulation of dihydroxyphenylacetaldehyde extracellular levels in vivo in the rat striatum after different kinds of pharmacological treatment. | Fornai, F., et al. 2000. Brain Res. 861: 126-34. PMID: 10751572
- Binding of [3H]dihydrotetrabenazine and [125I]azidoiodoketanserin photoaffinity labeling of the monoamine transporter of platelet 5-HT organelles. | Cesura, AM., et al. 1990. Eur J Pharmacol. 186: 95-104. PMID: 2149340
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- Concurrent Inhibition of Vesicular Monoamine Transporter 2 Does Not Protect Against 3,4-Methylenedioxymethamphetamine (Ecstasy) Induced Neurotoxicity. | Cholanians, AB., et al. 2019. Toxicol Sci. 170: 157-166. PMID: 30923810
- Brain norepinephrine and convulsions in the genetically epilepsy-prone rat: sex-dependent responses to Ro 4-1284 treatment. | Mishra, PK., et al. 1988. Life Sci. 42: 1131-7. PMID: 3347143
- Neuronal sodium homoeostatis and axoplasmic amine concentration determine calcium-independent noradrenaline release in normoxic and ischemic rat heart. | Schömig, A., et al. 1988. Circ Res. 63: 214-26. PMID: 3383376
- Effects of amfonelic acid, alpha-methyltyrosine, Ro 4-1284 and haloperidol pretreatment on the depletion of striatal dopamine by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice. | Fuller, RW. and Hemrick-Luecke, SK. 1985. Res Commun Chem Pathol Pharmacol. 48: 17-25. PMID: 3873102
- Depletion of epinephrine in rat hypothalamus by Ro 4-1284: influence of pargyline and harmaline. | Fuller, RW. and Hemrick-Luecke, SK. 1980. Brain Res Bull. 5: 589-91. PMID: 6903452
- Effect of a reserpine-like agent on the release and metabolism of [3H]NA in cell bodies and terminals. | Filinger, EJ. 1994. Gen Pharmacol. 25: 1039-43. PMID: 7835622
- Monoamine oxidase-A inhibitors and dopamine metabolism in rat caudatus: evidence that an increased cytosolic level of dopamine displaces reversible monoamine oxidase-A inhibitors in vivo. | Colzi, A., et al. 1993. J Pharmacol Exp Ther. 265: 103-11. PMID: 8473998
- Uptake and retention kinetics of para-fluorine-18-fluorobenzylguanidine in isolated rat heart. | Berry, CR., et al. 1996. J Nucl Med. 37: 2011-6. PMID: 8970525
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ro 4-1284, 5 mg | sc-255523 | 5 mg | $128.00 |