Molecular structure of Ro-32-0432, CAS Number: 145333-02-4
Ro-32-0432 (CAS 145333-02-4)
See product citations (13)
Application:
Ro-32-0432 is a cell-permeable, selective PKC inhibitor
CAS Number:
145333-02-4
Molecular Weight:
489.01
Molecular Formula:
C28H28N4O2•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Ro-32-0432 is a cell-permeable selective inhibitor of PKC displaying a 10-fold greater selectivity for PKC-alpha (IC50 = 9.3 nM) and a 4-fold greater selectivity for PKC-betaI over PKC- epsilon (IC50 = 108 nM). Ro-32-0432 prevents T cell-driven chronic inflammatory responses in several rat models. Ro-32-0432 represents an approach to elucidate the mechanisms of interaction between PKC and the immune system.
Ro-32-0432 (CAS 145333-02-4) References
- Modulation by dopamine D1-like receptors of synaptic transmission and NMDA receptors in rat nucleus accumbens is attenuated by the protein kinase C inhibitor Ro 32-0432. | Chergui, K. and Lacey, MG. 1999. Neuropharmacology. 38: 223-31. PMID: 10218863
- Involvement of G protein-coupled receptor kinase-6 in desensitization of CGRP receptors. | Aiyar, N., et al. 2000. Eur J Pharmacol. 403: 1-7. PMID: 10969137
- Leptin stimulates catecholamine synthesis in a PKC-dependent manner in cultured porcine adrenal medullary chromaffin cells. | Takekoshi, K., et al. 2001. Endocrinology. 142: 4861-71. PMID: 11606454
- Bryostatin enhancement of memory in Hermissenda. | Kuzirian, AM., et al. 2006. Biol Bull. 210: 201-14. PMID: 16801495
- c-Src mediates thrombin-induced NF-kappaB activation and IL-8/CXCL8 expression in lung epithelial cells. | Lin, CH., et al. 2006. J Immunol. 177: 3427-38. PMID: 16920985
- Inhibition of PKC activity blocks the increase of ETB receptor expression in cerebral arteries. | Henriksson, M., et al. 2006. BMC Pharmacol. 6: 13. PMID: 17129394
- Ro 32-0432 attenuates mecamylamine-precipitated nicotine withdrawal syndrome in mice. | Singh, TG., et al. 2013. Naunyn Schmiedebergs Arch Pharmacol. 386: 197-204. PMID: 23274455
- Pharmacologic protein kinase Cα inhibition uncouples human platelet-stimulated angiogenesis from collagen-induced aggregation. | Moncada de la Rosa, C., et al. 2013. J Pharmacol Exp Ther. 345: 15-24. PMID: 23386249
- Functionally selective signaling for morphine and fentanyl antinociception and tolerance mediated by the rat periaqueductal gray. | Morgan, MM., et al. 2014. PLoS One. 9: e114269. PMID: 25503060
- Angiotensin II stimulates melanogenesis via the protein kinase C pathway. | Liu, LH., et al. 2015. Exp Ther Med. 10: 1528-1532. PMID: 26622519
- Effect of PKC inhibitor on experimental autoimmune myocarditis in Lewis rats. | Zhong, C., et al. 2017. Oncotarget. 8: 54187-54198. PMID: 28903333
- Scopoletin Stimulates Melanogenesis via cAMP/PKA Pathway and Partially p38 Activation. | Kim, DS., et al. 2017. Biol Pharm Bull. 40: 2068-2074. PMID: 28943528
- Protein Kinase C-Mediated Hyperphosphorylation and Lateralization of Connexin 43 Are Involved in Autoimmune Myocarditis-Induced Prolongation of QRS Complex. | Zhong, C., et al. 2022. Front Physiol. 13: 815301. PMID: 35418879
- Ro 32-0432, a selective and orally active inhibitor of protein kinase C prevents T-cell activation. | Birchall, AM., et al. 1994. J Pharmacol Exp Ther. 268: 922-9. PMID: 8114006
- Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C. | Wilkinson, SE., et al. 1993. Biochem J. 294 (Pt 2): 335-7. PMID: 8373348
Inhibitor of:
Mnk1, PKC, PKC ε, REM2, and Ser/Thr Protein Kinase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ro-32-0432, 1 mg | sc-3549 | 1 mg | $103.00 | |||
Ro-32-0432, 5 mg | sc-3549A | 5 mg | $388.00 |