RO 2433 (CAS 863329-66-2)
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RO 2433 is of interest in the field of nucleoside analog research due to its modified sugar moiety. It is studied for its potential to interfere with nucleic acid synthesis, which can provide insights into the replication and transcription processes of cells. Researchers employ RO 2433 in the exploration of RNA biochemistry, particularly in the context of viral replication, given that certain viruses rely on RNA-dependent RNA polymerases for their life cycle. In addition, RO 2433 is used as a tool to study the structural requirements for substrate recognition and catalysis by these polymerases. Its incorporation into oligonucleotides is also of interest for the development of probes and primers in molecular biology applications. The compound′s modified structure allows scientists to investigate the stability and dynamics of nucleic acids when introduced with such analogs.
RO 2433 (CAS 863329-66-2) References
- Characterization of the metabolic activation of hepatitis C virus nucleoside inhibitor beta-D-2'-Deoxy-2'-fluoro-2'-C-methylcytidine (PSI-6130) and identification of a novel active 5'-triphosphate species. | Ma, H., et al. 2007. J Biol Chem. 282: 29812-20. PMID: 17698842
- The mechanism of action of beta-D-2'-deoxy-2'-fluoro-2'-C-methylcytidine involves a second metabolic pathway leading to beta-D-2'-deoxy-2'-fluoro-2'-C-methyluridine 5'-triphosphate, a potent inhibitor of the hepatitis C virus RNA-dependent RNA polymerase. | Murakami, E., et al. 2008. Antimicrob Agents Chemother. 52: 458-64. PMID: 17999967
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
RO 2433, 100 mg | sc-472597 | 100 mg | $306.00 |