Date published: 2026-4-1

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RO 106-9920 (CAS 62645-28-7)

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Alternate Names:
6-(Phenylsulfinyl)tetrazolo[1,5-b]pyridazine
Application:
RO 106-9920 is a NF-kB-dependent cytokine expression, 5-LO, and EGFR inhibitor
CAS Number:
62645-28-7
Purity:
>95%
Molecular Weight:
245.3
Molecular Formula:
C10H7N5OS
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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RO 106-9920 is an organic compound that features a benzene ring and a tetrazole ring within its heterocyclic aromatic structure. With its sulfur-containing heterocyclic nature, it finds wide-ranging applications in organic synthesis and materials science. Serving as a versatile reagent, it has been instrumental in various reactions, including the synthesis of amino acids, peptides, peptidomimetics, and heterocycles. It has also demonstrated its catalytic properties, facilitating the synthesis of various compounds. The mechanism of action of RO 106-9920 depends on its interaction with the substrate. In peptide synthesis, it functions as a coupling reagent, facilitating the formation of a peptide bond between two amino acids. In heterocycle synthesis, it acts as a nucleophilic reagent, enabling the formation of a five-membered ring structure. Additionally, in catalytic reactions, it acts as a Lewis acid, promoting the reaction between the substrate and the catalyst.


RO 106-9920 (CAS 62645-28-7) References

  1. A small molecule ubiquitination inhibitor blocks NF-kappa B-dependent cytokine expression in cells and rats.  |  Swinney, DC., et al. 2002. J Biol Chem. 277: 23573-81. PMID: 11950839
  2. Amitriptyline induces nuclear transcription factor-kappaB-dependent glutamate transporter upregulation in chronic morphine-infused rats.  |  Tai, YH., et al. 2008. Neuroscience. 153: 823-31. PMID: 18400403
  3. NF-kappaB inhibitors impair platelet activation responses.  |  Malaver, E., et al. 2009. J Thromb Haemost. 7: 1333-43. PMID: 19566544
  4. Signal pathways JNK and NF-kappaB, identified by global gene expression profiling, are involved in regulation of TNFalpha-induced mPGES-1 and COX-2 expression in gingival fibroblasts.  |  Båge, T., et al. 2010. BMC Genomics. 11: 241. PMID: 20398340
  5. Nuclear factor κB is a key transcription factor in the duodenal contractility alterations induced by lipopolysaccharide.  |  Hernández, LV., et al. 2011. Exp Physiol. 96: 1151-62. PMID: 21890516
  6. Hepcidin regulation by BMP signaling in macrophages is lipopolysaccharide dependent.  |  Wu, X., et al. 2012. PLoS One. 7: e44622. PMID: 23028567
  7. Novel signaling mechanisms of intracellular angiotensin II-induced NHE3 expression and activation in mouse proximal tubule cells.  |  Li, XC., et al. 2012. Am J Physiol Renal Physiol. 303: F1617-28. PMID: 23034941
  8. Regulation of neutrophil extracellular trap formation by anti-inflammatory drugs.  |  Lapponi, MJ., et al. 2013. J Pharmacol Exp Ther. 345: 430-7. PMID: 23536315
  9. Angiotensin II activates NF-κB through AT1A receptor recruitment of β-arrestin in cultured rat vascular smooth muscle cells.  |  Morinelli, TA., et al. 2013. Am J Physiol Cell Physiol. 304: C1176-86. PMID: 23576578
  10. Oxidized low density lipoprotein enhanced RANKL expression in human osteoblast-like cells. Involvement of ERK, NFkappaB and NFAT.  |  Mazière, C., et al. 2013. Biochim Biophys Acta. 1832: 1756-64. PMID: 23756197
  11. Functional responses and molecular mechanisms involved in histone-mediated platelet activation.  |  Carestia, A., et al. 2013. Thromb Haemost. 110: 1035-45. PMID: 23965842
  12. Regulation of platelet responses triggered by Toll-like receptor 2 and 4 ligands is another non-genomic role of nuclear factor-kappaB.  |  Rivadeneyra, L., et al. 2014. Thromb Res. 133: 235-43. PMID: 24331207

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

RO 106-9920, 1 mg

sc-203240
1 mg
$141.00

RO 106-9920, 5 mg

sc-203240A
5 mg
$599.00