Molecular structure of Ro 10-5824 dihydrochloride, CAS Number: 189744-46-5
Ro 10-5824 dihydrochloride (CAS 189744-46-5)
Alternate Names:
5-[(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl)methyl]-2-methyl-4-pyrimidinamine dihydrochloride
Application:
Ro 10-5824 dihydrochloride is a selective D4DR (dopamine D4 receptor) partial agonist
CAS Number:
189744-46-5
Molecular Weight:
353.29
Molecular Formula:
C17H20N4•2HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Ro 10-5824 dihydrochloride is a selective D4DR (dopamine D4 receptor) partial agonist with high binding affinity (Ki = 5.2 nM). Ro 10-5824 displays 250-fold selectivity over D3 receptors and > 1000-fold selectivity over D2, D1 and D5 receptors.
Ro 10-5824 dihydrochloride (CAS 189744-46-5) References
- RO-10-5824 is a selective dopamine D4 receptor agonist that increases novel object exploration in C57 mice. | Powell, SB., et al. 2003. Neuropharmacology. 44: 473-81. PMID: 12646284
- A-412997 is a selective dopamine D4 receptor agonist in rats. | Moreland, RB., et al. 2005. Pharmacol Biochem Behav. 82: 140-7. PMID: 16153699
- Agonist and antagonist properties of antipsychotics at human dopamine D4.4 receptors: G-protein activation and K+ channel modulation in transfected cells. | Newman-Tancredi, A., et al. 2008. Int J Neuropsychopharmacol. 11: 293-307. PMID: 17897483
- Selective dopamine D4 receptor agonist (A-412997) improves cognitive performance and stimulates motor activity without influencing reward-related behaviour in rat. | Woolley, ML., et al. 2008. Behav Pharmacol. 19: 765-76. PMID: 19020411
- Dopamine D4 receptor, but not the ADHD-associated D4.7 variant, forms functional heteromers with the dopamine D2S receptor in the brain. | González, S., et al. 2012. Mol Psychiatry. 17: 650-62. PMID: 21844870
- Circadian-related heteromerization of adrenergic and dopamine D₄ receptors modulates melatonin synthesis and release in the pineal gland. | González, S., et al. 2012. PLoS Biol. 10: e1001347. PMID: 22723743
- L-type Ca²⁺ channel activity determines modulation of GABA release by dopamine in the substantia nigra reticulata and the globus pallidus of the rat. | Recillas-Morales, S., et al. 2014. Neuroscience. 256: 292-301. PMID: 24505607
- Stimulation of dopamine D4 receptors in the paraventricular nucleus of the hypothalamus of male rats induces hyperphagia: involvement of glutamate. | Tejas-Juárez, JG., et al. 2014. Physiol Behav. 133: 272-81. PMID: 24805978
- Effect of dopamine D4 receptor agonists on sleep architecture in rats. | Nakazawa, S., et al. 2015. Prog Neuropsychopharmacol Biol Psychiatry. 63: 6-13. PMID: 25985889
- Behavioral and neurophysiological effects of Ro 10-5824, a dopamine D4 receptor partial agonist, in common marmosets. | Nakazawa, S., et al. 2015. Psychopharmacology (Berl). 232: 3287-95. PMID: 26041337
- Synergistically acting agonists and antagonists of G protein-coupled receptors prevent photoreceptor cell degeneration. | Chen, Y., et al. 2016. Sci Signal. 9: ra74. PMID: 27460988
- Bidirectional modulation of hippocampal synaptic plasticity by Dopaminergic D4-receptors in the CA1 area of hippocampus. | Navakkode, S., et al. 2017. Sci Rep. 7: 15571. PMID: 29138490
- Sepsis induced cognitive impairments by disrupting hippocampal parvalbumin interneuron-mediated inhibitory network via a D4-receptor mechanism. | Ji, M., et al. 2020. Aging (Albany NY). 12: 2471-2484. PMID: 32019903
- Neural network disturbance in the medial prefrontal cortex might contribute to cognitive impairments induced by neuroinflammation. | Ji, MH., et al. 2020. Brain Behav Immun. 89: 133-144. PMID: 32505714
- Reduced inhibitory and excitatory input onto parvalbumin interneurons mediated by perineuronal net might contribute to cognitive impairments in a mouse model of sepsis-associated encephalopathy. | Zhang, L., et al. 2023. Neuropharmacology. 225: 109382. PMID: 36543316
Activator of:
D4DR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ro 10-5824 dihydrochloride, 10 mg | sc-204886 | 10 mg | $125.00 | |||
Ro 10-5824 dihydrochloride, 50 mg | sc-204886A | 50 mg | $525.00 |