Molecular structure of Ro 04-5595 hydrochloride, CAS Number: 194089-07-1
Ro 04-5595 hydrochloride (CAS 194089-07-1)
Application:
Ro 04-5595 hydrochloride is a selective NMDA receptor antagonist
CAS Number:
194089-07-1
Molecular Weight:
368.30
Molecular Formula:
C19H22ClNO2•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Ro 04-5595 hydrochloride is a selective antagonist for NMDAε2-containing NMDA receptors with a Ki value of 31 nM.
Ro 04-5595 hydrochloride (CAS 194089-07-1) References
- Estrogen-like activity of tamoxifen and raloxifene on NMDA receptor binding and expression of its subunits in rat brain. | Cyr, M., et al. 2001. Neuropsychopharmacology. 25: 242-57. PMID: 11425508
- Alteration of glutamate receptors in the striatum of dyskinetic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated monkeys following dopamine agonist treatment. | Calon, F., et al. 2002. Prog Neuropsychopharmacol Biol Psychiatry. 26: 127-38. PMID: 11853103
- Levodopa-induced motor complications are associated with alterations of glutamate receptors in Parkinson's disease. | Calon, F., et al. 2003. Neurobiol Dis. 14: 404-16. PMID: 14678757
- Implication of NMDA receptors in the antidyskinetic activity of cabergoline, CI-1041, and Ro 61-8048 in MPTP monkeys with levodopa-induced dyskinesias. | Ouattara, B., et al. 2009. J Mol Neurosci. 38: 128-42. PMID: 18704766
- NMDA receptor hypofunction in the prelimbic cortex increases sensitivity to the rewarding properties of opiates via dopaminergic and amygdalar substrates. | Bishop, SF., et al. 2011. Cereb Cortex. 21: 68-80. PMID: 20392811
- Defective dentate nucleus GABA receptors in essential tremor. | Paris-Robidas, S., et al. 2012. Brain. 135: 105-16. PMID: 22120148
- Effect of oestrogen receptors on brain NMDA receptors of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mice. | Al-Sweidi, S., et al. 2012. J Neuroendocrinol. 24: 1375-85. PMID: 22672467
- Chronic treatment with MPEP, an mGlu5 receptor antagonist, normalizes basal ganglia glutamate neurotransmission in L-DOPA-treated parkinsonian monkeys. | Morin, N., et al. 2013. Neuropharmacology. 73: 216-31. PMID: 23756168
- NR2A-NMDA Receptor Blockade Reverses the Lack of Morphine Analgesia Without Affecting Chronic Pain Status in a Fibromyalgia-Like Mouse Model. | Neyama, H., et al. 2020. J Pharmacol Exp Ther. 373: 103-112. PMID: 31941720
- In vitro binding properties in rat brain of [3H]Ro 25-6981, a potent and selective antagonist of NMDA receptors containing NR2B subunits. | Mutel, V., et al. 1998. J Neurochem. 70: 2147-55. PMID: 9572302
Inhibitor of:
NMDA.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ro 04-5595 hydrochloride, 10 mg | sc-204885 | 10 mg | $165.00 | |||
Ro 04-5595 hydrochloride, 50 mg | sc-204885A | 50 mg | $715.00 |