RNF141 Antibody (J-23): sc-101119

RNF141 Antibody (J-23) is a mouse monoclonal IgG1 kappa light chain antibody that detects RNF141 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). RNF141 (J-23) antibody is available as the non-conjugated form. RNF141, also known as ring finger protein 141, ZFP26, or ZNF230, is a 230 amino acid protein characterized by the presence of a RING-type zinc finger motif, which is crucial for its function in the ubiquitination pathway of protein degradation. This motif consists of a conserved cysteine-rich domain capable of binding two zinc atoms, a feature that is essential for structural integrity and functional activity. RNF141 is expressed in two isoforms due to alternative splicing, with isoform 1 primarily found in the testis and isoform 2 expressed in various tissues including the brain, heart, pancreas, kidney, and skeletal muscle. The specific expression of isoform 1 in the testis suggests a vital role as a transcription factor during spermatogenesis, and its absence in azoospermic men highlights its importance in testis development and male fertility. Anti-RNF141 antibody (J-23) enables researchers to gain insights into the mechanisms of protein degradation and the regulatory roles of RNF141 in reproductive biology.

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RNF141 Antibody (J-23) References:

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