Molecular structure of RNA Polymerase III Inhibitor, CAS Number: 577784-91-9
RNA Polymerase III Inhibitor Inhibitor (CAS 577784-91-9)
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Alternate Names:
RNA Polymerase III Inhibitor is also known as ML-60218.
Application:
RNA Polymerase III Inhibitor is a cell-permeable indazolo-sulfonamide compound displaying inhibitory activity against RNA Polymerase III.
CAS Number:
577784-91-9
Purity:
≥97%
Molecular Weight:
452.37
Molecular Formula:
C19H15Cl2N3O2S2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
RNA Polymerase III Inhibitor is a cell-permeable indazolo-sulfonamide compound that displays broad-spectrum inhibitory activity against RNA Polymerase III. RNA Polymerase III Inhibitor inhibits cell growth in yeast by preventing RNA Pol III-mediated tRNA transcription. RNA Polymerase III Inhibitor is able to compromise the structural integrity of viroplasms and rotavirus double-layered particles. When combined with an HDAC inhibtor, RNA Polymerase III Inhibitor was shown induce cell cycle arrest and apoptotic cell death in pancreatic adenocarcinoma cells.
RNA Polymerase III Inhibitor Inhibitor (CAS 577784-91-9) References
- Novel small-molecule inhibitors of RNA polymerase III. | Wu, L., et al. 2003. Eukaryot Cell. 2: 256-64. PMID: 12684375
- Targeting developmental regulators of zebrafish exocrine pancreas as a therapeutic approach in human pancreatic cancer. | Yee, NS., et al. 2012. Biol Open. 1: 295-307. PMID: 23213420
- Neutrophil Extracellular Trap Formation Is Independent of De Novo Gene Expression. | Sollberger, G., et al. 2016. PLoS One. 11: e0157454. PMID: 27310721
- C/EBPβ mediates RNA polymerase III-driven transcription of oncomiR-138 in malignant gliomas. | Di Pascale, F., et al. 2018. Nucleic Acids Res. 46: 336-349. PMID: 29136251
- Identification of a Small Molecule That Compromises the Structural Integrity of Viroplasms and Rotavirus Double-Layered Particles. | Eichwald, C., et al. 2018. J Virol. 92: PMID: 29142132
- A Nucleolar Stress-Specific p53-miR-101 Molecular Circuit Functions as an Intrinsic Tumor-Suppressor Network. | Fujiwara, Y., et al. 2018. EBioMedicine. 33: 33-48. PMID: 30049386
- A Short Tandem Repeat-Enriched RNA Assembles a Nuclear Compartment to Control Alternative Splicing and Promote Cell Survival. | Yap, K., et al. 2018. Mol Cell. 72: 525-540.e13. PMID: 30318443
- ATF4 couples MYC-dependent translational activity to bioenergetic demands during tumour progression. | Tameire, F., et al. 2019. Nat Cell Biol. 21: 889-899. PMID: 31263264
- Gapmer Antisense Oligonucleotides Targeting 5S Ribosomal RNA Can Reduce Mature 5S Ribosomal RNA by Two Mechanisms. | Pollak, AJ., et al. 2020. Nucleic Acid Ther. 30: 312-324. PMID: 32589504
- TDP-43 prevents endogenous RNAs from triggering a lethal RIG-I-dependent interferon response. | Dunker, W., et al. 2021. Cell Rep. 35: 108976. PMID: 33852834
- Lytic Infection with Murine Gammaherpesvirus 68 Activates Host and Viral RNA Polymerase III Promoters and Enhances Noncoding RNA Expression. | Knox, AN., et al. 2021. J Virol. 95: e0007921. PMID: 33910955
- Invading viral DNA triggers dsRNA synthesis by RNA polymerase II to activate antiviral RNA interference in Drosophila. | de Faria, IJS., et al. 2022. Cell Rep. 39: 110976. PMID: 35732126
- CRISPR screening reveals a dependency on ribosome recycling for efficient SARS-CoV-2 programmed ribosomal frameshifting and viral replication. | Rehfeld, F., et al. 2023. Cell Rep. 42: 112076. PMID: 36753415
Inhibitor of:
Enzyme, and RNA Polymerase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
RNA Polymerase III Inhibitor, 10 mg | sc-222257 | 10 mg | $367.00 |