Molecular structure of RN 1747, CAS Number: 1024448-59-6
RN 1747 (CAS 1024448-59-6)
Alternate Names:
1-(4-Chloro-2-nitrophenyl)sulfonyl- 4-benzylpiperazine; 4-chloro-2-nitro-1-((4-benzylpiperazinyl)sulfonyl)benzene; 1-[(4-Chloro-2-nitrophenyl)sulfonyl]-4-(phenylmethyl)-piperazine
Application:
RN 1747 is a potent and selective TRPV4 agonist
CAS Number:
1024448-59-6
Purity:
>97%
Molecular Weight:
395.87
Molecular Formula:
C17H18CIN3O4S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
Technical Information
Safety Information
SDS & Certificate of Analysis
RN 1747 is a selective TRPV4 agonist. Shown to display selectivity over other TRP channels. Also may act to antagonize TRPM8 at relevant concentrations.
RN 1747 (CAS 1024448-59-6) References
- Identification and characterization of novel TRPV4 modulators. | Vincent, F., et al. 2009. Biochem Biophys Res Commun. 389: 490-4. PMID: 19737537
- TRPV4 activates autonomic and behavioural warmth-defence responses in Wistar rats. | Vizin, RC., et al. 2015. Acta Physiol (Oxf). 214: 275-89. PMID: 25739906
- Alterations in serotonin, transient receptor potential channels and protease-activated receptors in rats with irritable bowel syndrome attenuated by Shugan decoction. | Shi, HL., et al. 2015. World J Gastroenterol. 21: 4852-63. PMID: 25944998
- TRP Channels in Insect Stretch Receptors as Insecticide Targets. | Nesterov, A., et al. 2015. Neuron. 86: 665-71. PMID: 25950634
- Effect of capsaicin on thermoregulation: an update with new aspects. | Szolcsányi, J. 2015. Temperature (Austin). 2: 277-96. PMID: 27227029
- Endogenous TRPV4 Expression of a Hybrid Neuronal Cell Line N18D3 and Its Utilization to Find a Novel Synthetic Ligand. | Yoo, S., et al. 2017. J Mol Neurosci. 63: 422-430. PMID: 29090425
- TRPV4: a Sensor for Homeostasis and Pathological Events in the CNS. | Kumar, H., et al. 2018. Mol Neurobiol. 55: 8695-8708. PMID: 29582401
- Calcium, Sodium, and Transient Receptor Potential Channel Expression in Human Fetal Midbrain-Derived Neural Progenitor Cells. | Stanslowsky, N., et al. 2018. Stem Cells Dev. 27: 976-984. PMID: 29779467
- Small molecules for fat combustion: targeting obesity. | Liu, J., et al. 2019. Acta Pharm Sin B. 9: 220-236. PMID: 30976490
- The Transient Receptor Potential Vanilloid 4 Agonist RN-1747 Inhibits the Calcium Response to Histamine. | Pfanzagl, B., et al. 2019. Pharmacology. 104: 166-172. PMID: 31212298
- Significance of transient receptor potential vanilloid 4 and aquaporin 5 co-expression in the rat uterus at term. | Ducza, E., et al. 2019. Heliyon. 5: e02697. PMID: 31687520
- Hydrophobic Derivatives of Sulfated Hyaluronic Acid as Drug Delivery Systems for Multi-Target Intra-Articular Treatment of Post-Traumatic Osteoarthritis. | Guarise, C., et al. 2022. J Pharm Sci. 111: 2505-2513. PMID: 35405122
- Cutaneous TRPV4 Channels Activate Warmth-Defense Responses in Young and Adult Birds. | Cristina-Silva, C., et al. 2022. Front Physiol. 13: 892828. PMID: 35910562
- Selection of preferred thermal environment and cold-avoidance responses in rats rely on signals transduced by the dorsal portion of the lateral funiculus of the spinal cord. | Vizin, RCL., et al. 2023. Temperature (Austin). 10: 121-135. PMID: 37187830
Inhibitor of:
TRPM8.Activator of:
TRPV.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
RN 1747, 10 mg | sc-296274 | 10 mg | $143.00 | |||
RN 1747, 50 mg | sc-296274A | 50 mg | $571.00 |