RJR 2403 oxalate is a CNS selective AChR agonist, showing high selectivity for the α4β2 subtype (Ki values are 26 and 36000 nM for α4β2 and α7 receptors, respectively).
Bencherif et al (1996) RJR-2403: a nicotinic agonist with CNS selectivity I. In vitro characterization. J.Pharmacol.Exp.Ther. 279 1413. Lippiello et al (1996) RJR-2403: a nicotinic agonist with CNS selectivity II. In vivo characterization. J.Pharmacol.Exp.Ther. 279 1422. Damaj et al (1999) Antinociceptive and pharmacological effects of metanicotine, a selective nicotinic agonist. J.Pharmacol.Exp.Ther. 291 390.
Soluble in water (100 mM).
Store at -20° C
506.2° C at 760 mmHg (Predicted)
n20D ~1.55 (Predicted)
AChRα4β2: Ki= 26 nM; AChRα7: Ki= 36 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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