RJR 2403 oxalate CAS: 183288-99-5
MF: C10H14N2 C2H2O4
MW: 252.27
RJR 2403 oxalate is a selective AChR angonist.

RJR 2403 oxalate (CAS 183288-99-5)

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Alternate Names: Metanicotine; TC-2403
Application: RJR 2403 oxalate is a selective AChR angonist
CAS Number: 183288-99-5
Purity: ≥99%
Molecular Weight: 252.27
Molecular Formula: C10H14N2 C2H2O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

RJR 2403 oxalate is a CNS selective AChR agonist, showing high selectivity for the α4β2 subtype (Ki values are 26 and 36000 nM for α4β2 and α7 receptors, respectively).


References

Bencherif et al (1996) RJR-2403: a nicotinic agonist with CNS selectivity I. In vitro characterization. J.Pharmacol.Exp.Ther. 279 1413. Lippiello et al (1996) RJR-2403: a nicotinic agonist with CNS selectivity II. In vivo characterization. J.Pharmacol.Exp.Ther. 279 1422. Damaj et al (1999) Antinociceptive and pharmacological effects of metanicotine, a selective nicotinic agonist. J.Pharmacol.Exp.Ther. 291 390.

Physical State :
Solid
Solubility :
Soluble in water (100 mM).
Storage :
Store at -20° C
Boiling Point :
506.2° C at 760 mmHg (Predicted)
Refractive Index :
n20D ~1.55 (Predicted)
Ki Data :
AChRα4β2: Ki= 26 nM; AChRα7: Ki= 36 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
23298272
MDL Number :
MFCD12828738
SMILES :
CNCC/C=C/C1=CN=CC=C1.C(=O)(C(=O)O)O

Download SDS (MSDS)

Certificate of Analysis

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PMID: # 22820264  Neuroscience. 222: 10-9.

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