RIZ Antibody (33AT1045): sc-130256

RIZ Antibody (33AT1045) is a mouse monoclonal IgG1 antibody that detects RIZ protein of mouse, rat, and human origin by western blotting (WB) and enzyme-linked immunosorbent assay (ELISA). Anti-RIZ antibody (33AT1045) is available as a non-conjugated format. RIZ protein, encoded by the Rb-interacting zinc finger gene RIZ1, plays a crucial role in regulating cell growth and apoptosis, making RIZ1 a significant player in cancer biology. Located on chromosome 1p36, a region frequently altered in various human tumors, RIZ1 is often mutated in colorectal, gastric, and endometrial cancers. RIZ protein functions as a candidate tumor suppressor, with RIZ1′s ability to induce cell cycle arrest and apoptosis being vital for maintaining cellular homeostasis. RIZ exists in two isoforms: PR-plus RIZ1, which is typically lost or underexpressed in cancer cells, and PR-minus RIZ2, which remains present. The imbalance between these two isoforms may contribute to tumorigenesis, highlighting RIZ′s importance in cancer research and therapy.

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RIZ Antibody (33AT1045) References:

1. The retinoblastoma protein-interacting zinc finger gene RIZ in 1p36-linked cancers.  |  Huang, S. 1999. Front Biosci. 4: D528-32. PMID: 10369808
2. Identification of a DNA binding protein cooperating with estrogen receptor as RIZ (retinoblastoma interacting zinc finger protein).  |  Medici, N., et al. 1999. Biochem Biophys Res Commun. 264: 983-9. PMID: 10544042
3. Frequent frameshift mutations of RIZ in sporadic gastrointestinal and endometrial carcinomas with microsatellite instability.  |  Piao, Z., et al. 2000. Cancer Res. 60: 4701-4. PMID: 10987271
4. RIZ, the retinoblastoma protein interacting zinc finger gene, is mutated in genetically unstable cancers of the pancreas, stomach, and colorectum.  |  Sakurada, K., et al. 2001. Genes Chromosomes Cancer. 30: 207-11. PMID: 11135439
5. Adenovirus expressing RIZ1 in tumor suppressor gene therapy of microsatellite-unstable colorectal cancers.  |  Jiang, GL. and Huang, S. 2001. Cancer Res. 61: 1796-8. PMID: 11280725
6. Frameshift mutations of RIZ, but no point mutations in RIZ1 exons in malignant melanomas with deletions in 1p36.  |  Poetsch, M., et al. 2002. Oncogene. 21: 3038-42. PMID: 12082534
7. Altered expression of retinoblastoma protein-interacting zinc finger gene, RIZ, in human leukaemia.  |  Sasaki, O., et al. 2002. Br J Haematol. 119: 940-8. PMID: 12472571
8. Detection of frameshift mutations of RIZ in gastric cancers with microsatellite instability.  |  Pan, KF., et al. 2004. World J Gastroenterol. 10: 2719-22. PMID: 15309726
9. The Zn-finger domain of RIZ protein promotes MCF-7 cell proliferation.  |  Rossi, M., et al. 2004. Cancer Lett. 215: 229-37. PMID: 15488642