Ritanserin CAS: 87051-43-2
Ritanserin is potent and long-acting 5-HT2 receptor antagonist.

Ritanserin (CAS 87051-43-2)

Ritanserin | CAS 87051-43-2 is rated 5.0 out of 5 by 1.
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Alternate Names: Tiserton; Ritanserina
Application: Ritanserin is potent and long-acting 5-HT2 receptor antagonist
CAS Number: 87051-43-2
Molecular Weight: 477.57
Molecular Formula: C27H25F2N3OS
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Ritanserin is a potent and long-acting SR-2A (5-HT2 receptor) antagonist (Ki = 0.39 nM).


References

Janssen (1985) Pharmacology of potent and selective S2-serotonergic antagonists. J.Cardiovasc.Pharmacol. 7 S2. Leysen et al (1985) Receptor-binding properties in vitro and in vivo of ritanserin. Mol.Pharmacol. 27 600. Watanabe et al (1992) Syntheses and 5

Physical State :
Solid
Solubility :
Soluble in water (1.3 mg/ml), ethanol (25 mM), DMSO (100 mM), and methanol (>10 mg/ml). Insoluble in dilute aqueous base.
Storage :
Store at 4° C
Melting Point :
145.5° C
Boiling Point :
619° C
Refractive Index :
n20D 1.65 (Predicted)
IC50 :
Serotonin 2 receptor: IC50 = 0.4 nM (rat); Serotonin 2a receptor: IC50 = 0.4 nM (rat); Rat: IC50 = 3.47 nM; D2 receptor: IC50 = 12 nM (rat); Adrenergic receptor α-1: IC50 = 37 nM (rat)
Ki Data :
Serotonin 2 receptor: Ki= 0.26 nM (rat); 5-HT2 receptor: Ki= 0.39 nM; Serotonin 2a receptor: Ki= 1.7 nM (rat); Dopamine D2 receptor: Ki= 3 nM (rat); Histamine H1 receptor: Ki= 6 nM (guinea pig)
pK Values :
pKb: 6.25
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
MDL Number :
MFCD00069341
SMILES :
CC1=C(C(=O)N2C=CSC2=N1)CCN3CCC(=C(C4=CC=C(C=C4)F)C5=CC=C(C=C5)F)CC3

Download SDS (MSDS)

Certificate of Analysis

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Ritanserin (CAS 87051-43-2)  Product Citations

See how others have used Ritanserin (CAS 87051-43-2). Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 26961099  Nozaki, K. et al. 2016. J. Neurophysiol. 115: 2997-3007.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Garcia Garcia-Pedraza el al. (PubMed ID 25854421) used Ritanserin to inactivate 5-HT and prevent vasoconstriction to study 5-HT1D activation by nitric oxide. -SCBT Publication Review
Date published: 2015-04-22
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