RING1 Antibody (8C12F4): sc-517221

RING1 Antibody (8C12F4) is a mouse monoclonal IgG1 antibody that detects RING1 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). RING1 (8C12F4) antibody is available as the non-conjugated form. RING1 protein plays a crucial role in the regulation of gene expression through involvement in chromatin remodeling and transcriptional repression, which is vital for maintaining cellular identity and preventing inappropriate gene activation. Specifically, RING1 is part of the Polycomb group (PcG) proteins that form multimeric complexes essential for the repression of developmental genes, thereby influencing cell fate decisions during embryogenesis. A RING finger motif in RING1 allows interaction with other regulatory proteins, facilitating function in chromatin modification. RING1′s ability to repress the expression of proto-oncogenes such as c-Jun and c-fos underscores importance in cellular growth regulation and oncogenesis. Loss of RING1 expression has been linked to the differentiation of B cells, indicating significant role in germinal center development and immune response.

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RING1 Antibody (8C12F4) References:

1. Transcriptional repression mediated by the human polycomb-group protein EED involves histone deacetylation.  |  van der Vlag, J. and Otte, AP. 1999. Nat Genet. 23: 474-8. PMID: 10581039
2. Cutting edge: polycomb gene expression patterns reflect distinct B cell differentiation stages in human germinal centers.  |  Raaphorst, FM., et al. 2000. J Immunol. 164: 1-4. PMID: 10604983
3. Loss- and gain-of-function mutations show a polycomb group function for Ring1A in mice.  |  del Mar Lorente, M., et al. 2000. Development. 127: 5093-100. PMID: 11060235
4. The Polycomb group protein EZH2 is upregulated in proliferating, cultured human mantle cell lymphoma.  |  Visser, HP., et al. 2001. Br J Haematol. 112: 950-8. PMID: 11298590
5. The bmi-1 and mel-18 gene products define a new family of DNA-binding proteins involved in cell proliferation and tumorigenesis.  |  Goebl, MG. 1991. Cell. 66: 623. PMID: 1823128
6. Identification and preliminary characterization of a protein motif related to the zinc finger.  |  Lovering, R., et al. 1993. Proc Natl Acad Sci U S A. 90: 2112-6. PMID: 7681583
7. RING1 is associated with the polycomb group protein complex and acts as a transcriptional repressor.  |  Satijn, DP., et al. 1997. Mol Cell Biol. 17: 4105-13. PMID: 9199346
8. RING1 interacts with multiple Polycomb-group proteins and displays tumorigenic activity.  |  Satijn, DP. and Otte, AP. 1999. Mol Cell Biol. 19: 57-68. PMID: 9858531

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-RING1 Antibody (8C12F4) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-RING1 Antibody (8C12F4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

RING1 Antibody (8C12F4) Specifications

Alternate Product Name: RING1

Product Clone Name: 8C12F4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids: 79-263

Epitope Target: RING1

Epitope Species: human

Product Reactivity/Detection: RING1

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), FCM, ELISA

Vialing Information: Each vial contains 50 µg IgG₁ in 0.5 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for RING1 Antibody (8C12F4): N/A