Rimexolone (CAS 49697-38-3)
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Rimexolone, a derivative of prednisolone, is a synthetic glucocorticoid that possesses anti-inflammatory and immunosuppressive properties. It functions by binding to the cytosolic glucocorticoid receptor and activating specific glucocorticoid response elements, leading to altered gene expression. This results in the induction of anti-inflammatory protein IkappaB-alpha synthesis and inhibition of nuclear factor kappaB (NFkappa B) synthesis. Consequently, the production of pro-inflammatory cytokines such as interleukin-1 (IL-1), IL-2, and IL-6 is reduced, and the activation of cytotoxic T-lymphocytes is inhibited. These mechanisms contribute to an overall reduction in chronic inflammation and autoimmune reactions. Rimexolone acts as a glucocorticoid receptor agonist, exerting its anti-inflammatory effects through the modulation of lipocortins and the biosynthesis of prostaglandins and leukotrienes.
Rimexolone (CAS 49697-38-3) References
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Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Rimexolone, 100 mg | sc-505859 | 100 mg | $400.00 |