Molecular structure of Rifaximin, CAS Number: 80621-81-4
Rifaximin (CAS 80621-81-4)
See product citations (2)
Alternate Names:
Rifaximin is also known as Rifacol.
Application:
Rifaximin is a Pregnane X receptor agonist and antibiotic that inhibits RNA synthesis and activates PXR.
CAS Number:
80621-81-4
Purity:
≥99%
Molecular Weight:
785.88
Molecular Formula:
C43H51N3O11
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
Rifaximin is an antibiotic that inhibits RNA synthesis and acts as a PXR (pregnane-X-receptor) activator. Rifaximin is a derivative of rifamycin that may act to act strongly against Enterococcus, Streptococcus and Staphylococcus, with less activity against Enterobacteriaceae. Rifaximin has been in a variety of gastrointestinal and intestinal epithelial cell studies. Rifaximin reduced the number of colon tumors and suppressed expression of TNFα and Il-1β induced in a colon cancer.
Rifaximin (CAS 80621-81-4) References
- In vitro activity and fecal concentration of rifaximin after oral administration. | Jiang, ZD., et al. 2000. Antimicrob Agents Chemother. 44: 2205-6. PMID: 10898704
- Experimental and clinical pharmacology of rifaximin, a gastrointestinal selective antibiotic. | Scarpignato, C. and Pelosini, I. 2006. Digestion. 73 Suppl 1: 13-27. PMID: 16498249
- Pretreatment of epithelial cells with rifaximin alters bacterial attachment and internalization profiles. | Brown, EL., et al. 2010. Antimicrob Agents Chemother. 54: 388-96. PMID: 19858255
- Bile acids improve the antimicrobial effect of rifaximin. | Darkoh, C., et al. 2010. Antimicrob Agents Chemother. 54: 3618-24. PMID: 20547807
- Rifaximin: a nonsystemic rifamycin antibiotic for gastrointestinal infections. | Cottreau, J., et al. 2010. Expert Rev Anti Infect Ther. 8: 747-60. PMID: 20586560
- Therapeutic role of rifaximin in inflammatory bowel disease: clinical implication of human pregnane X receptor activation. | Cheng, J., et al. 2010. J Pharmacol Exp Ther. 335: 32-41. PMID: 20627999
- Pregnane-X-receptor mediates the anti-inflammatory activities of rifaximin on detoxification pathways in intestinal epithelial cells. | Mencarelli, A., et al. 2010. Biochem Pharmacol. 80: 1700-7. PMID: 20816942
- Clinical trial: the combination of rifaximin with partially hydrolysed guar gum is more effective than rifaximin alone in eradicating small intestinal bacterial overgrowth. | Furnari, M., et al. 2010. Aliment Pharmacol Ther. 32: 1000-6. PMID: 20937045
- Inhibition of NF-κB by a PXR-dependent pathway mediates counter-regulatory activities of rifaximin on innate immunity in intestinal epithelial cells. | Mencarelli, A., et al. 2011. Eur J Pharmacol. 668: 317-24. PMID: 21806984
- Rifaximin alters intestinal bacteria and prevents stress-induced gut inflammation and visceral hyperalgesia in rats. | Xu, D., et al. 2014. Gastroenterology. 146: 484-96.e4. PMID: 24161699
- Herbal therapy is equivalent to rifaximin for the treatment of small intestinal bacterial overgrowth. | Chedid, V., et al. 2014. Glob Adv Health Med. 3: 16-24. PMID: 24891990
- Beneficial effects of Rifaximin in post-infectious irritable bowel syndrome mouse model beyond gut microbiota. | Jin, Y., et al. 2018. J Gastroenterol Hepatol. 33: 443-452. PMID: 28573746
- Rifaximin Alters Intestinal Microbiota and Prevents Progression of Ankylosing Spondylitis in Mice. | Yang, L., et al. 2019. Front Cell Infect Microbiol. 9: 44. PMID: 30886835
- Rifaximin. A review of its antibacterial activity, pharmacokinetic properties and therapeutic potential in conditions mediated by gastrointestinal bacteria. | Gillis, JC. and Brogden, RN. 1995. Drugs. 49: 467-84. PMID: 7774516
Inhibitor of:
RNA pol σ 70.Activator of:
PXR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Rifaximin, 100 mg | sc-205841B | 100 mg | $28.00 | |||
Rifaximin, 250 mg | sc-205841C | 250 mg | $42.00 | |||
Rifaximin, 500 mg | sc-205841 | 500 mg | $79.00 | |||
Rifaximin, 1 g | sc-205841A | 1 g | $105.00 | |||
Rifaximin, 5 g | sc-205841D | 5 g | $406.00 |