Molecular structure of Rifamycin B, CAS Number: 13929-35-6
Rifamycin B (CAS 13929-35-6)
Alternate Names:
4-O-(Carboxymethyl)rifamycin
Application:
Rifamycin B is Rifamycin B is a Rifamycin derivative used as antibacterial agent
CAS Number:
13929-35-6
Molecular Weight:
755.80
Molecular Formula:
C39H49NO14
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Rifamycin B is a naturally occurring ansamycin antibiotic compound that is extensively studied for its role as a starting material in the production of various rifamycin derivatives. In research, it is often involved in studies of antibiotic biosynthesis, where understanding the enzymatic pathways that lead to its production can reveal insights into natural product synthesis. Additionally, Rifamycin B is used as a precursor in synthetic chemistry for the generation of semi-synthetic rifamycins, which are compounds of interest due to their antibacterial properties. The research on this compound also delves into the understanding of its mechanism of action, which involves inhibiting bacterial RNA synthesis by binding to the DNA-dependent RNA polymerase.
Rifamycin B (CAS 13929-35-6) References
- Isolation and characterization of 27-O-demethylrifamycin SV methyltransferase provides new insights into the post-PKS modification steps during the biosynthesis of the antitubercular drug rifamycin B by Amycolatopsis mediterranei S699. | Xu, J., et al. 2003. Arch Biochem Biophys. 411: 277-88. PMID: 12623077
- Optimization of rifamycin B fermentation in shake flasks via a machine-learning-based approach. | Bapat, PM. and Wangikar, PP. 2004. Biotechnol Bioeng. 86: 201-8. PMID: 15052640
- Identification of tailoring genes involved in the modification of the polyketide backbone of rifamycin B by Amycolatopsis mediterranei S699. | Xu, J., et al. 2005. Microbiology (Reading). 151: 2515-2528. PMID: 16079331
- Screening of rifamycin producing marine sponge bacteria by LC-MS-MS. | Hewavitharana, AK., et al. 2007. J Chromatogr B Analyt Technol Biomed Life Sci. 852: 362-6. PMID: 17301003
- Development of balanced medium composition for improved rifamycin B production by isolated Amycolatopsis sp. RSP-3. | Mahalaxmi, Y., et al. 2009. Lett Appl Microbiol. 49: 533-8. PMID: 19793193
- Whole genome sequence of the rifamycin B-producing strain Amycolatopsis mediterranei S699. | Verma, M., et al. 2011. J Bacteriol. 193: 5562-3. PMID: 21914879
- Modification of rifamycin polyketide backbone leads to improved drug activity against rifampicin-resistant Mycobacterium tuberculosis. | Nigam, A., et al. 2014. J Biol Chem. 289: 21142-52. PMID: 24923585
- Improved Rifamycin B Production by Nocardia mediterranei MTCC 14 under Solid-State Fermentation through Process Optimization. | Vastrad, BM., et al. 2014. Biochem Res Int. 2014: 621309. PMID: 25371823
- A feedback regulatory model for RifQ-mediated repression of rifamycin export in Amycolatopsis mediterranei. | Lei, C., et al. 2018. Microb Cell Fact. 17: 14. PMID: 29375035
- Prediction of Transcription Factors and Their Involvement in Regulating Rifamycin Production in Amycolatopsis mediterranei S699. | Singhvi, N., et al. 2020. Indian J Microbiol. 60: 310-317. PMID: 32655198
- Differential mass spectrometry-based proteome analyses unveil major regulatory hubs in rifamycin B production in Amycolatopsis mediterranei. | Singhvi, N., et al. 2021. J Proteomics. 239: 104168. PMID: 33662614
- Transformation of rifamycin B with growing and resting cells of Curvularia lunata. | Banerjee, UC. 1993. Enzyme Microb Technol. 15: 1037-41. PMID: 7764294
- Use of a macrocyclic antibiotic, rifamycin B, and indirect detection for the resolution of racemic amino alcohols by CE. | Armstrong, DW., et al. 1994. Anal Chem. 66: 1690-5. PMID: 8030783
- Enantiomeric resolution using the macrocyclic antibiotics rifamycin B and rifamycin SV as chiral selectors for capillary electrophoresis. | Ward, TJ., et al. 1995. J Chromatogr A. 715: 337-44. PMID: 8520671
- Overproduction of rifamycin B by Amycolatopsis mediterranei and its relationship with the toxic effect of barbital on growth. | Mejía, A., et al. 1998. J Antibiot (Tokyo). 51: 58-63. PMID: 9531988
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Rifamycin B, 50 mg | sc-391444 | 50 mg | $320.00 | |||
Rifamycin B, 500 mg | sc-391444A | 500 mg | $2290.00 |