Ricin B Antibody (RB691): sc-52194

Ricin B Antibody (RB691) is a mouse monoclonal IgG2b antibody that detects Ricin B from Ricinus communis by western blotting (WB). Anti-Ricin B antibody (RB691) is available in a non-conjugated form, specifically designed for researchers studying ricin, a potent type II ribosomal inactivating protein. The Ricin B chain (RTB) plays a crucial role in toxin′s mechanism of action by facilitating entry of the toxic A chain into target cells. RTB functions as a lectin, binding to specific carbohydrate moieties, particularly beta-D-galactopyranoside, present on glycoprotein surfaces. This binding enables A chain internalization, which then depurinates adenine 4324 in the 28S rRNA of the 60S ribosomal subunit, inhibiting protein synthesis. Understanding RTB structure and function is vital for developing therapeutic strategies against ricin poisoning and advancing research in cellular uptake mechanisms of toxins.

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Ricin B Antibody (RB691) References:

1. Comparative studies on kinetics of inhibition of protein synthesis in intact cells by ricin and a conjugate of ricin B-chain with momordin.  |  Sharma, S., et al. 1999. Mol Cell Biochem. 200: 133-41. PMID: 10569193
2. Entry of ricin and Shiga toxin into cells: molecular mechanisms and medical perspectives.  |  Sandvig, K. and van Deurs, B. 2000. EMBO J. 19: 5943-50. PMID: 11080141
3. The Gal/GalNAc-specific lectin from the plant pathogenic basidiomycete Rhizoctonia solani is a member of the ricin-B family.  |  Candy, L., et al. 2001. Biochem Biophys Res Commun. 282: 655-61. PMID: 11401511
4. Ricin triggers apoptotic morphological changes through caspase-3 cleavage of BAT3.  |  Wu, YH., et al. 2004. J Biol Chem. 279: 19264-75. PMID: 14960581
5. Immunological characteristics associated with the protective efficacy of antibodies to ricin.  |  Maddaloni, M., et al. 2004. J Immunol. 172: 6221-8. PMID: 15128810
6. Ricin: mechanism of toxicity, clinical manifestations, and vaccine development. A review.  |  Doan, LG. 2004. J Toxicol Clin Toxicol. 42: 201-8. PMID: 15214627
7. Characterization of a novel high-affinity monoclonal immunoglobulin G antibody against the ricin B subunit.  |  McGuinness, CR. and Mantis, NJ. 2006. Infect Immun. 74: 3463-70. PMID: 16714577

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Ricin B Antibody (RB691) has 1 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Ricin B Antibody (RB691) Specifications

Alternate Product Name: Ricin B

Product Clone Name: RB691

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b

Amino Acids:

Epitope Target: Ricin B

Epitope Species: Ricinus communis

Product Reactivity/Detection: RAC120 and the B-chain of RCA60

Species Reactivity/Detection: Ricinus communis

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB

Vialing Information: Each vial contains 100 µg IgG_2b in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for Ricin B Antibody (RB691): N/A