Ricin A Antibody (CP75): sc-52186

Ricin A Antibody (CP75) is a mouse monoclonal IgG1 antibody that detects Ricin A protein of Ricinus communis origin by western blotting (WB) and enzyme-linked immunosorbent assay (ELISA). Anti-Ricin A antibody (CP75) is available as the non-conjugated format. Ricin A, a type II ribosomal inactivating protein, plays a critical role in inhibiting protein biosynthesis through RNA N-glycosidase activity, which is essential for understanding toxic effects. The A chain of Ricin A (RTA) specifically targets the 28S rRNA of the 60S ribosomal subunit, where RTA depurinates adenine 4324, leading to disruption of protein synthesis in eukaryotic cells. This mechanism of action highlights RTA′s importance in cellular toxicity and potential therapeutic interventions. The crystal structure of Ricin A provides insights into functional domains and interactions, which are crucial for developing strategies to counteract effects. With specificity for Ricinus communis, Ricin A (CP75) monoclonal antibody serves as an invaluable tool for researchers studying molecular mechanisms of ricin toxicity and applications in toxicology and biochemistry.

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Ricin A Antibody (CP75) References:

1. Ricin triggers apoptotic morphological changes through caspase-3 cleavage of BAT3.  |  Wu, YH., et al. 2004. J Biol Chem. 279: 19264-75. PMID: 14960581
2. Reductive activation of ricin and ricin A-chain immunotoxins by protein disulfide isomerase and thioredoxin reductase.  |  Bellisola, G., et al. 2004. Biochem Pharmacol. 67: 1721-31. PMID: 15081871
3. Ricin A-chain substrate specificity in RNA, DNA, and hybrid stem-loop structures.  |  Amukele, TK. and Schramm, VL. 2004. Biochemistry. 43: 4913-22. PMID: 15109249
4. Immunological characteristics associated with the protective efficacy of antibodies to ricin.  |  Maddaloni, M., et al. 2004. J Immunol. 172: 6221-8. PMID: 15128810
5. Oligosaccharide side chains on human secretory IgA serve as receptors for ricin.  |  Mantis, NJ., et al. 2004. J Immunol. 172: 6838-45. PMID: 15153502
6. Endosomal ricin transport: involvement of Rab4- and Rab5-positive compartments.  |  Moisenovich, M., et al. 2004. Histochem Cell Biol. 121: 429-39. PMID: 15221413
7. Protein disulphide-isomerase reduces ricin to its A and B chains in the endoplasmic reticulum.  |  Spooner, RA., et al. 2004. Biochem J. 383: 285-93. PMID: 15225124
8. Lack of dendritic cell maturation by the plant toxin ricin.  |  Smith, DC., et al. 2004. Eur J Immunol. 34: 2149-57. PMID: 15259012

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Ricin A Antibody (CP75) has 0 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Ricin A Antibody (CP75) Specifications

Alternate Product Name: Ricin A

Product Clone Name: CP75

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: Ricin A

Epitope Species: Ricinus communis

Product Reactivity/Detection: RCA120 and the A chain of RCA60

Species Reactivity/Detection: Ricinus communis

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Ricin A Antibody (CP75): N/A