Ribosomal Protein L23a Antibody (3E11): sc-517097

Ribosomal Protein L23a Antibody (3E11) is a mouse monoclonal IgG2a kappa light chain antibody that detects Ribosomal Protein L23a (RPL23a) of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-RPL23a antibody (3E11) is available as the non-conjugated format. RPL23a, also known as MDA20, is a crucial component of the 60S ribosomal subunit, consisting of 156 amino acids, and is predominantly expressed in tissues such as the heart, pancreas, and skeletal muscle. RPL23a (3E11) monoclonal antibody plays a significant role in studying the assembly and function of ribosomes, which are essential for protein synthesis in all living cells. RPL23a is involved in mediating growth inhibition and may act as a target for interferons, which are critical for the immune response. Cytoplasmic localization of RPL23a is vital for facilitating the translation of mRNA into proteins, a process fundamental for cellular function and growth. Additionally, RPL23a is associated with multiple processed pseudogenes scattered throughout the genome, reflecting its evolutionary history and the complexity of ribosomal protein gene regulation.

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Ribosomal Protein L23a Antibody (3E11) References:

1. A complete map of the human ribosomal protein genes: assignment of 80 genes to the cytogenetic map and implications for human disorders.  |  Uechi, T., et al. 2001. Genomics. 72: 223-30. PMID: 11401437
2. Distinct modes of signal recognition particle interaction with the ribosome.  |  Pool, MR., et al. 2002. Science. 297: 1345-8. PMID: 12193787
3. Regulated release of L13a from the 60S ribosomal subunit as a mechanism of transcript-specific translational control.  |  Mazumder, B., et al. 2003. Cell. 115: 187-98. PMID: 14567916
4. The molecular mechanics of eukaryotic translation.  |  Kapp, LD. and Lorsch, JR. 2004. Annu Rev Biochem. 73: 657-704. PMID: 15189156
5. Structure and evolution of mammalian ribosomal proteins.  |  Wool, IG., et al. 1995. Biochem Cell Biol. 73: 933-47. PMID: 8722009
6. Suppression of human ribosomal protein L23A expression during cell growth inhibition by interferon-beta.  |  Jiang, H., et al. 1997. Oncogene. 14: 473-80. PMID: 9053844
7. Cloning, sequencing, gene organization, and localization of the human ribosomal protein RPL23A gene.  |  Fan, W., et al. 1997. Genomics. 46: 234-9. PMID: 9417910
8. Importin beta, transportin, RanBP5 and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cells.  |  Jäkel, S. and Görlich, D. 1998. EMBO J. 17: 4491-502. PMID: 9687515

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Ribosomal Protein L23a Antibody (3E11) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-Ribosomal Protein L23a Antibody (3E11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Ribosomal Protein L23a Antibody (3E11) Specifications

Alternate Product Name: Ribosomal Protein L23a

Product Clone Name: 3E11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 59-156

Epitope Target: Ribosomal Protein L23a

Epitope Species: human

Product Reactivity/Detection: Ribosomal Protein L23a

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for Ribosomal Protein L23a Antibody (3E11): N/A