Date published: 2025-10-2

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Rhodamine Phenylglyoxal (CAS 2309313-01-5)

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Alternate Names:
Rh-PG; Citrulline-specific Probe
CAS Number:
2309313-01-5
Molecular Weight:
713.74
Molecular Formula:
C39H35N7O7
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Rhodamine Phenylglyoxal is a biochemistry fluorescent dye. It labels and tracks proteins and other biomolecules within living cells. Rhodamine Phenylglyoxal is a small molecule that can be easily conjugated to proteins, peptides, and nucleic acids, making it versatile for studying cellular processes. Its bright fluorescence and high photostability make it an ideal choice for live cell imaging and super-resolution microscopy. Rhodamine Phenylglyoxal has minimal cytotoxicity, allowing for long-term imaging experiments without affecting cell viability. Its high specificity for labeling primary amines makes it useful for studying protein-protein interactions and post-translational modifications. Rhodamine Phenylglyoxal is a fluorescent probe in biochemistry and cell biology due to its versatility, brightness, and low cytotoxicity.


Rhodamine Phenylglyoxal (CAS 2309313-01-5) References

  1. Seeing citrulline: development of a phenylglyoxal-based probe to visualize protein citrullination.  |  Bicker, KL., et al. 2012. J Am Chem Soc. 134: 17015-8. PMID: 23030787
  2. Coral cell separation and isolation by fluorescence-activated cell sorting (FACS).  |  Rosental, B., et al. 2017. BMC Cell Biol. 18: 30. PMID: 28851289
  3. A Novel Biological Role for Peptidyl-Arginine Deiminases: Citrullination of Cathelicidin LL-37 Controls the Immunostimulatory Potential of Cell-Free DNA.  |  Wong, A., et al. 2018. J Immunol. 200: 2327-2340. PMID: 29475987
  4. The Rheumatoid Arthritis-Associated Citrullinome.  |  Tilvawala, R., et al. 2018. Cell Chem Biol. 25: 691-704.e6. PMID: 29628436
  5. Citrullination Inactivates Nicotinamide- N-methyltransferase.  |  Nemmara, VV., et al. 2018. ACS Chem Biol. 13: 2663-2672. PMID: 30044909
  6. Development of Activity-Based Proteomic Probes for Protein Citrullination.  |  Nemmara, VV. and Thompson, PR. 2019. Curr Top Microbiol Immunol. 420: 233-251. PMID: 30203394
  7. Citrullination facilitates cross-reactivity of rheumatoid factor with non-IgG1 Fc epitopes in rheumatoid arthritis.  |  Trela, M., et al. 2019. Sci Rep. 9: 12068. PMID: 31427662
  8. Insights into the study and origin of the citrullinome in rheumatoid arthritis.  |  Fert-Bober, J., et al. 2020. Immunol Rev. 294: 133-147. PMID: 31876028
  9. Aldol sensor-inspired fluorescent probes for measuring protein citrullination.  |  Chen, H., et al. 2020. Org Biomol Chem. 18: 5120-5124. PMID: 32598414
  10. Elucidating Citrullination by Mass Spectrometry and Its Role in Disease Pathogenesis.  |  Vitorino, R., et al. 2021. J Proteome Res. 20: 38-48. PMID: 32966086
  11. Neutrophil-mediated carbamylation promotes articular damage in rheumatoid arthritis.  |  O'Neil, LJ., et al. 2020. Sci Adv. 6: PMID: 33115748
  12. Novel antiviral activity of PAD inhibitors against human beta-coronaviruses HCoV-OC43 and SARS-CoV-2.  |  Pasquero, S., et al. 2022. Antiviral Res. 200: 105278. PMID: 35288208
  13. Comparison of MALDI and ESI for Relative Quantification of Citrullination via Skewed Isotopic Distribution Patterns  |  Shin, E., & Cha, S. 2015. Bulletin of the Korean Chemical Society. 36(5): 1373-1377.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Rhodamine Phenylglyoxal, 250 µg

sc-477139A
250 µg
$315.00

Rhodamine Phenylglyoxal, 500 µg

sc-477139
500 µg
$505.00

Rhodamine Phenylglyoxal, 1 mg

sc-477139B
1 mg
$872.00