Molecular structure of Rho Kinase Inhibitor V, CAS Number: 1072906-02-5
Rho Kinase Inhibitor V (CAS 1072906-02-5)
Application:
Rho Kinase Inhibitor V is a cell-permeable and potent, ATP-binding pocket-targeting inhibitor of ROCK-II
CAS Number:
1072906-02-5
Molecular Weight:
321.3
Molecular Formula:
C18H15N3O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
A cell-permeable pyrazolyl carboxamide compound that acts as a potent, ATP-binding pocket-targeting inhibitor of ROCK-II and effectively inhibits the myosin light chain 2 phosphorylation on Thr18/Ser19 in A7r5 cells. It affects the activities of PKA, MRCK, Akt1 and CYP-450 enzymes only at much higher concentrations.
Rho Kinase Inhibitor V (CAS 1072906-02-5) References
- Discovery of substituted 4-(pyrazol-4-yl)-phenylbenzodioxane-2-carboxamides as potent and highly selective Rho kinase (ROCK-II) inhibitors. | Feng, Y., et al. 2008. J Med Chem. 51: 6642-5. PMID: 18834107
- The role of anaphylatoxins C3a and C5a in regulating innate and adaptive immune responses. | Peng, Q., et al. 2009. Inflamm Allergy Drug Targets. 8: 236-46. PMID: 19601884
- A high-content EMT screen identifies multiple receptor tyrosine kinase inhibitors with activity on TGFβ receptor. | Lotz-Jenne, C., et al. 2016. Oncotarget. 7: 25983-6002. PMID: 27036020
- Variations in basement membrane mechanics are linked to epithelial morphogenesis. | Chlasta, J., et al. 2017. Development. 144: 4350-4362. PMID: 29038305
Inhibitor of:
Protease, and Rock-2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Rho Kinase Inhibitor V, 5 mg | sc-222255 | 5 mg | $281.00 |